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Controlled-release antimicrobials for preventing biofilm formation in food and medical applications
Descriptive
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Title
Controlled-release antimicrobials for preventing biofilm formation in food and medical applications
Name
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Rosenberg
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Linda E.
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Linda E. Rosenberg
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author
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Chikindas
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Michael
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Advisory Committee
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Michael Chikindas
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chair
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Takhistov
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Paul
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Advisory Committee
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Paul Takhistov
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internal member
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Daun
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Henryk
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Advisory Committee
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Henryk Daun
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dissertation committee member
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
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theses
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2008
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2008-05
Language
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English
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electronic
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v, 75 pages
Abstract
Bacterial biofilms generally are more resistant to stresses as compared to free planktonic cells. Therefore, the discovery of antimicrobial stress factors that have strong inhibitory effects on bacterial biofilm formation would have great impact on the food, personal care, and medical industries. Biofilm formation can be prevented through controlled release of nature-derived antimicrobials formulated into polymer systems, especially those featuring multiple stresses as hurdles for the bacteria to overcome to prevent the development of resistance. Salicylate-based poly(anhydride-esters) have previously been shown to inhibit biofilm formation. Our research evaluated the effect of salicylate-based poly(anhydride-esters) on biofilm forming Salmonella enterica serovar Typhimurium. The results indicate that the salicylic acid-based polymers do interfere with biofilm formation through a combination of pH effects and a thus-far-unknown mechanism. Systems combining pH stress with the controlled release of natural antimicrobials have great potential to prevent biofilm development in many environments to prevent adverse outcomes, especially implant contamination and foodborne illness.
Note
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M.S.
Note
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Includes bibliographical references (p. 67-74).
Subject
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Topic
Food Science
Subject
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Topic
Biofilms
Subject
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Topic
Anti-infective agents
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17379
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ETD_800
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NjNbRU
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doi:10.7282/T38052ZV
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ETD graduate
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Rights
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The author owns the copyright to this work.
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Copyright protected
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Open
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Linda Rosenberg
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Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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