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Learning and neurogenesis: are new cells rescued from death with each new learning experience?

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TitleInfo (displayLabel = Citation Title); (type = uniform)
Title
Learning and neurogenesis: are new cells rescued from death with each new learning experience?
TitleInfo (displayLabel = Other Title); (type = alternative)
Title
Are new cells rescued from death with each new learning experience?
Name (ID = NAME001); (type = personal)
NamePart (type = family)
Sisti
NamePart (type = given)
Helene M.
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Helene M. Sisti
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author
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Shors
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Tracey
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Advisory Committee
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Tracey Jo Shors
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chair
Name (ID = NAME003); (type = personal)
NamePart (type = family)
Matzel
NamePart (type = given)
Louis
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Advisory Committee
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Louis Matzel
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internal member
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NamePart (type = family)
Glass
NamePart (type = given)
Arnold
Affiliation
Advisory Committee
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Arnold Glass
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internal member
Name (ID = NAME005); (type = personal)
NamePart (type = family)
DiCicco-Bloom
NamePart (type = given)
Emanuel
Affiliation
Advisory Committee
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Emanuel DiCicco-Bloom
Role
RoleTerm (authority = RULIB)
outside member
Name (ID = NAME006); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME007); (type = corporate)
NamePart
Graduate School - New Brunswick
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school
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Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2008
DateOther (qualifier = exact); (type = degree)
2008-05
Language
LanguageTerm
English
PhysicalDescription
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electronic
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application/pdf
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text/xml
Extent
vii, 117 pages
Abstract
New cells in the adult hippocampus become apoptotic, e.g. begin programmed cell death, about one week after they are generated. If animals begin to learn a hippocampal-dependent task, at precisely the time when these cells would normally begin apoptosis, then the fate of these cells is altered. Instead of dying, the newly generated cells survive. These new cells differentiate into mature neurons and become fully integrated into the hippocampal network. Thus far, much of this work has focused on a single training experience. An important question has yet to be addressed: are new cells rescued from death with each new learning experience? In the present series of experiments, animals were trained with two phases of eyeblink conditioning. During the first phase, animals either learned the same task, a different one, or remained in their home cage. A single injection of BrdU was given after the first training experience had been completed, and one week before the start of the second training experience. Animals that were trained with a single phase of eyeblink conditioning retained more BrdU-labeled cells than those trained with two phases or no training at all. When animals were re-categorized based on learning during the second phase, instead of by training condition, there was a significant positive correlation between improvement and number of new neurons. Animals that demonstrated a larger degree of improvement retained more one week old neurons than animals that did not learn very well, regardless of previous experience. Overall, these data suggest that even during a second training experience, learning can rescue one week old neurons from death.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references (p. 85-91).
Subject (ID = SUBJ1); (authority = RUETD)
Topic
Psychology
Subject (ID = SUBJ2); (authority = ETD-LCSH)
Topic
Learning, Psychology of
Subject (ID = SUBJ3); (authority = ETD-LCSH)
Topic
Developmental neurobiology
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17414
Identifier
ETD_979
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3XP7594
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
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Open
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Name
Helene Sisti
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Type
Permission or license
Detail
Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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