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The bioavailability of 90MX cranberry powder and quercetin when administered to horses
Descriptive
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Title
The bioavailability of 90MX cranberry powder and quercetin when administered to horses
Name
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Malone
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Sara Rae
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Sara Rae Malone
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author
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McKeever
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Kenneth
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Advisory Committee
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Kenneth H McKeever
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chair
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Malinowski
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Karyn
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Advisory Committee
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Karyn Malinowski
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internal member
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NamePart
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Vorsa
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Nicholi
Affiliation
Advisory Committee
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Nicholi Vorsa
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outside member
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Rutgers University
Role
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degree grantor
Name
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NamePart
Graduate School - New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated
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2008
DateOther
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2008-10
Language
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English
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electronic
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application/pdf
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text/xml
Extent
viii, 61 pages
Abstract
The subject of this thesis was to investigate the bioavailability of a commercially available cranberry powder (90MX) from Ocean Spray® and quercetin when administered to horses. The hypothesis states that flavonols from a commercially available 90MX cranberry powder and quercetin would both be bioavailable to the horse. Bioavailability was determined by the appearance and identification of flavonols in horse plasma, urine, and/or muscle after dosing via nasogastric tube. For the first study, three healthy unfit Standardbred mares were used in a random cross-over design. They received either 200 g of 90MX powder in 2 L of water (low dose = LD), 400 g of 90MX powder dissolved in 2 L of water (high dose = HD), or 2 L of water (control = CON). For the second study, the same three mares were given 6 g of quercetin in 2 L of water. Blood, urine, and muscle samples were collected pre-dosing and at 0.5, 1, 2, 4, 8, 16, and 24 h post-dosing. High performance liquid chromatography (HPLC) analysis of the samples showed trace amounts of flavonols in some plasma samples, but overall there were no quantitatively significant increase flavonols found in horse urine or plasma. HPLC analysis of the muscle samples did show an increase in quercetin (Q), Q-3 arabinopyranoside (Q-3-AP), M-3 galactoside (M-3-G), Q-3 rhamnoside (Q-3-R), Q-3 arabinofuranoside (Q-3-AF), and Q-3 galactoside (Q-3-G). Peak quantities of each flavonol (µg/g) in horse muscle were Q (1.96; 5.33), Q-3-AP (0.24; 0.05), M-3-G (0.80; 0.37), Q-3-R (0.55; 0.24). Q-3-AF (0.12; 0.07), Q-3-G (2.45; 1.22) for the LD and HD, respectively. In study two, there was no quantitatively measureable quercetin in plasma, urine, or muscle samples. These data show for the first time the uptake of an ingested flavonol compound (cranberry juice) into horse muscle. This lays the foundation for further investigation into the effects of flavonols on horse muscle which has been physiologically stressed by exercise or other variables.
Note
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M.S.
Note
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Includes bibliographical references (p. 48-51).
Subject
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Topic
Animal Sciences
Subject
(ID = SUBJ2);
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Topic
Bioflavonoids--Physiological effect
Subject
(ID = SUBJ3);
(authority = ETD-LCSH)
Topic
Polyphenols--Physiological effect
Subject
(ID = SUBJ4);
(authority = ETD-LCSH)
Topic
Quercetin--Physiological effect
Subject
(ID = SUBJ5);
(authority = ETD-LCSH)
Topic
Flavonoids--Physiological effect
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17519
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ETD_1109
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NjNbRU
Identifier
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doi:10.7282/T3Q81DD3
Genre
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ETD graduate
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Rights
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
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Open
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Name
Sara Malone
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Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Permission or license
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Non-exclusive ETD license
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License
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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