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Prostate cancer chemoprevention by dietary phytochemicals

Descriptive

TypeOfResource
Text
TitleInfo (ID = T-1)
Title
Prostate cancer chemoprevention by dietary phytochemicals
SubTitle
PartName
PartNumber
NonSort
Identifier
ETD_1407
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000050491
Language (objectPart = )
LanguageTerm (authority = ISO639-2); (type = code)
eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Pharmaceutical Science
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Prostate--Cancer
Subject (ID = SBJ-3); (authority = ETD-LCSH)
Topic
Cancer--Chemoprevention
Subject (ID = SBJ-4); (authority = ETD-LCSH)
Topic
Cancer--Diet therapy
Abstract
Prostate cancer is one of the most frequent diagnosed forms of cancer among men in the United States. It displays considerable clinical, morphological and biological heterogeneity. Integrated information regarding candidate genes, transcription factors and pathways implicated in prostate cancer development is crucial to help stall prostate cancer. Currently the number of patients suffering from this invasive disease is on the rise and given the fact that when clinically significant this disorder is associated with a high mortality rate, prevention may prove to be the best approach. Chemoprevention entails the use of preferably dietary agents to block or suppress the various stages of prostate carcinogenesis. Flavonoids, the essential components of fruits and vegetables can modulate transcription factor AP-1 and its upstream signaling cascades mainly ERK-MAPK and JNK-MAPK in human androgen insensitive prostate cancer (PC3) cells. Soy isoflavone concentrate can upregulate the expression of several phase II detoxifying and antioxidant genes in an NF-E2-related factor 2 (Nrf2) dependent manner. In addition to detoxifying genes, soy isoflavone concentrate can also modulate the expression of genes such as LATS2, GREB1, calpain and many more in an Nrf2 dependent manner. The expression of most of these genes has been shown to be altered in prostate cancer progression. Animal models that can mimick key events in prostate cancer progression provide a valuable tool in the development of anti cancer therapies. In one such transgenic model, curcumin or PEITC suppressed high grade PIN levels. However a combination of low doses of these agents worked remarkably well in suppressing tumors all together. A deeper insight at the process of cancer development in the same model revealed that indeed prostate carcinogenesis occurs by progressive suppression of Nrf2 and its related phase II detoxifying and antioxidant enzymes. Treatment with γ-tocopherol enriched mixed tocopherol diet, on the other hand, significantly increased expression of Nrf2 as well as phase II detoxifying and antioxidant enzymes. Likewise a mixed tocotrienol diet suppressed tumor incidence by modulating cell cycle control and pro-apoptotic proteins. Finally, the observed chemopreventive effects of the dietary agents were correlated with their and their metabolites' circulating plasma levels.
PhysicalDescription
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electronic resource
Extent
xiv, 199 p. : ill.
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application/pdf
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text/xml
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references (p. 178-196)
Note (type = statement of responsibility)
by Avantika Barve
Name (ID = NAME-1); (type = personal)
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Barve
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Avantika
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author
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Avantika Barve
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NamePart (type = family)
Kong
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Tony
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chair
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Advisory Committee
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Tony Kong
Name (ID = NAME-3); (type = personal)
NamePart (type = family)
Suh
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Nanjoo
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internal member
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Advisory Committee
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Nanjoo Suh
Name (ID = NAME-4); (type = personal)
NamePart (type = family)
Zhou
NamePart (type = given)
Renping
Role
RoleTerm (authority = RULIB); (type = )
internal member
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Advisory Committee
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Renping Zhou
Name (ID = NAME-5); (type = personal)
NamePart (type = family)
HUANG
NamePart (type = given)
MOU-TUAN
Role
RoleTerm (authority = RULIB); (type = )
outside member
Affiliation
Advisory Committee
DisplayForm
MOU-TUAN HUANG
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB); (type = )
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB); (type = )
school
OriginInfo
DateCreated (point = ); (qualifier = exact)
2009
DateOther (qualifier = exact); (type = degree)
2009-01
Place
PlaceTerm (type = code)
xx
Location
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NjNbRU
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = doi)
doi:10.7282/T3XS5VN5
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
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Type
Permission or license
Detail
Non-exclusive ETD license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
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License
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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ETD
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application/pdf
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application/x-tar
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3215360
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