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Arterial pressure-volume relation and augmentation index
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TypeOfResource
Text
TitleInfo
Title
Arterial pressure-volume relation and augmentation index
Identifier
ETD_1476
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051064
Identifier
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doi:10.7282/T3028RS7
Language
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(authority = ISO 639-3:2007);
(type = text)
English
Genre
(authority = marcgt)
theses
Subject
(authority = RUETD)
Topic
Biomedical Engineering
Subject
(authority = ETD-LCSH)
Topic
Arteries
Subject
(authority = ETD-LCSH)
Topic
Blood pressure
Subject
(authority = ETD-LCSH)
Topic
Hemodynamics
Abstract
(type = abstract)
Hypertension is the primary precursor to all forms of heart disease which according to the CDC continues to be the leading cause of death in the USA. A strong correlation between arterial stiffness and hypertension has been established. Similarly, a decrease in arterial compliance has been shown to be a major causative factor associated with hypertension. Consequently, many studies are designed to identify markers of the health of the arterial system. These markers have not been adequately defined.
To identify possible markers for quantifying arterial properties in hypertension, this thesis evaluates several popular methods for aortic compliance determination from measured aortic pressure and flow waveforms, and then establishes arterial pressure-volume relations as well as proposing new augmentation indices and comparing them with existing ones.
Simultaneously measured aortic pressure and flow waveforms were obtained from experiments performed on anesthetized mongrel dogs during control, methoxamine-induced hypertension and nitroprusside-induced vasodilation. Digitized data sets were analyzed based on hemodynamic equations established for arterial pressure-volume relation, arterial compliance and augmentation indices.
Results obtained highlighted the consistency in accuracy of the pressure-dependent compliance in predicting the aortic blood pressure. The average gradient of the volume-pressure decreased under hypertensive conditions indicative of the decreased compliance. The comparison of augmentation indices revealed that the most popular method actually produced the least significant distinction between the three conditions. However, all methods produced satisfactory ANOVA results (P < 0.001) for separation of means in differentiating control from hypertension and subsequent vasodilation.
To identify possible markers for quantifying arterial properties in hypertension, this thesis evaluates several popular methods for aortic compliance determination from measured aortic pressure and flow waveforms, and then establishes arterial pressure-volume relations as well as proposing new augmentation indices and comparing them with existing ones.
Simultaneously measured aortic pressure and flow waveforms were obtained from experiments performed on anesthetized mongrel dogs during control, methoxamine-induced hypertension and nitroprusside-induced vasodilation. Digitized data sets were analyzed based on hemodynamic equations established for arterial pressure-volume relation, arterial compliance and augmentation indices.
Results obtained highlighted the consistency in accuracy of the pressure-dependent compliance in predicting the aortic blood pressure. The average gradient of the volume-pressure decreased under hypertensive conditions indicative of the decreased compliance. The comparison of augmentation indices revealed that the most popular method actually produced the least significant distinction between the three conditions. However, all methods produced satisfactory ANOVA results (P < 0.001) for separation of means in differentiating control from hypertension and subsequent vasodilation.
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electronic resource
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viii, 73 p. : ill.
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application/pdf
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text/xml
Note
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M.S.
Note
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Includes bibliographical references (p. 60-66)
Note
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by Ronald Andre Pitt
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Pitt
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Ronald Andre
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author
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Ronald Andre Pitt
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Li
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John
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chair
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Advisory Committee
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John K-J Li
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Drzewiecki
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Gary
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internal member
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Advisory Committee
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Gary M Drzewiecki
Name
(type = personal)
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(type = family)
Shoane
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(type = given)
George
Role
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(authority = RULIB)
internal member
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Advisory Committee
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George K Shoane
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Rutgers University
Role
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated
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2009
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2009-01
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NjNbRU
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Genre
(authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
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Open
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(ID = 1)
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Permission or license
Detail
Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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6881280
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