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Pilot study of perchorate exposure in lactating women in an urban community in New Jersey
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Text
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Title
Pilot study of perchorate exposure in lactating women in an urban community in New Jersey
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ETD_2111
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051786
Language
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eng
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theses
Subject
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Topic
Public Health
Subject
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(authority = ETD-LCSH)
Topic
Mothers--Health and hygiene
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Lactation
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(authority = ETD-LCSH)
Topic
Perchlorates--Physiological effect
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(authority = ETD-LCSH)
Topic
Perchlorates--Health aspects--New Jersey
Abstract
Perchlorate is most widely known as a solid oxidant for missile and rocket propulsion systems and has been detected in drinking water, fruits, vegetables, and milk throughout New Jersey and most of the U.S. Perchlorate interferes with the uptake of iodine into the thyroid and may interfere with the development of the skeletal system and central nervous system of infants who ingest perchlorate. Therefore, it is important to understand the occurrence of perchlorate in breast milk. This study will allow us to acquire valuable information on human exposure to perchlorate through analyses of breast milk, urine, and drinking water. One hundred and six lactating mothers were recruited from the Eric B. Chandler health center in New Brunswick, NJ and provided consent to participate in this study. Each subject was asked to provide three sets of samples and complete a 24-hour dietary recall. Regression analyses showed that diet was the greatest predictor of perchlorate in breast milk and urine and that drinking water was not a major source of perchlorate. The average perchlorate level in drinking water samples was 0.168 ng/mL (n = 253), which is below New Jersey’s Maximum Contaminant Level of 5 ng/mL. Perchlorate was detected in all breast milk samples provided (n = 276). The average perchlorate level in breast milk was 6.80 ng/mL. These findings are consistent with widespread perchlorate exposure in lactating women and infants, and that breast milk is a viable exposure route for infants. Based on the measured perchlorate levels in breast milk, we estimate that 25% of infants 0-6 months of age would exceed the EPA’s reference dose of 0.0007 mg/kg/day. Breast-feeding is important in an infant’s growth and development. Therefore, it is important to gain a better understanding of environmental contaminant concentrations in human breast milk and other sources of infant nourishment.
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electronic resource
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xv, 155 p. : ill
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Ph.D.
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Includes bibliographical references (p. 97-102)
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by Marija Borjan
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Borjan
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Marija
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1979
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Marija Borjan
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Robson
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Mark
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chair
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Mark Gregory Robson
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Marcella
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Stephen
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internal member
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Stephen Marcella
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Greenberg
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Michael
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Michael Greenberg
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Zhang
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Jim
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Jim Zhang
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Blount
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Benjamin
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Benjamin Blount
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
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2009
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2009-10
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xx
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Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T31Z44M9
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ETD doctoral
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Rights
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The author owns the copyright to this work
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Copyright protected
Notice
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Open
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Borjan
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Marijan
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Marija Borjan
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Rutgers University. Graduate School - New Brunswick
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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