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An animal model of autism using GSTM1 knockout mice and early post-natal VPA-treatment
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Title
An animal model of autism using GSTM1 knockout mice and early post-natal VPA-treatment
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ETD_2028
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051926
Language
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eng
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theses
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Topic
Psychology
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(authority = ETD-LCSH)
Topic
Autism
Abstract
Autism is a behaviorally defined developmental disorder with unknown origin. However, its etiology most likely involves a gene by toxicant by age of exposure interaction. To test this hypothesis, mouse pups with a deletion of glutathione-S-transferase M1 (a gene associated with increased risk of autism and that codes for an enzyme involved in the management of toxicant-induced oxidative stress) and wild-type controls were exposed to valproic acid (a toxicant known to cause autism-like behavior deficits following prenatal exposure and one that exerts its toxic action, in part, by inducing oxidative stress) on post-natal day 14. It was observed that VPA-treatment resulted in significant increases in the number of cells staining for TUNEL in the hippocampus and cerebellum. There was also a gene by treatment by sex interaction with VPA- treated wild-type females having increased protection against VPA-induced cell death. VPA- treatment also resulted in long-lasting deficits in social behaviors and corresponding changes in brain chemistry. Collectively, these data expand our current animal model of autism by adding a genetic component in the form of an autism susceptibility gene. In addition, these results support the hypothesis that autism may be the result of a gene by toxicant interaction wherein both factors share a common feature of oxidative stress.
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electronic resource
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vii, 103 p. : ill.
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Ph.D.
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Includes bibliographical references (p. 51-61)
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by Carrie Leigh Yochum
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Yochum
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Carrie Leigh
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1979-
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author
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Carrie Leigh Yochum
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Wagner
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George
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chair
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Advisory Committee
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George C Wagner
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Otto
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Tim
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internal member
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Tim Otto
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Kusnecov
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Alex
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Alex Kusnecov
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Mirochnitchenko
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Oleg
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outside member
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Advisory Committee
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Oleg Mirochnitchenko
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
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2009
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2009-10
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xx
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Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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doi:10.7282/T3FB5332
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ETD doctoral
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Rights
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The author owns the copyright to this work
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Copyright protected
Notice
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Open
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Permission or license
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Yochum
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Carrie
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Carrie Yochum
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Rutgers University. Graduate School - New Brunswick
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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