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Inflammatory and antioxidant status of horses undergoing intense exercise and nutritional supplementation
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Text
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Inflammatory and antioxidant status of horses undergoing intense exercise and nutritional supplementation
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ETD_2422
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052127
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eng
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theses
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Topic
Endocrinology and Animal Biosciences
Subject
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(authority = ETD-LCSH)
Topic
Antioxidants--Therapeutic use
Subject
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(authority = ETD-LCSH)
Topic
Dietary supplements--Therapeutic use
Abstract
Markers of inflammation and antioxidant status were used to partially characterize physiological responses to a single bout of intense, exhaustive exercise in healthy Standardbreds, and to evaluate anti-inflammatory and antioxidant properties of an antioxidant enzyme supplement, with a particular focus on joint health. Main objectives were to 1) identify a model of exercise-induced inflammation by comparing inflammatory responses to different modes of exercise, 2) evaluate effects of supplemental superoxide dismutase (SOD) on exercise-induced inflammatory response and antioxidant status, and 3) evaluate effects of repeated arthrocentesis, exercise, and SOD supplementation on markers of inflammation and cartilage metabolism, in horses. For the first study, a repeated sprint exercise test was identified as the most strenuous compared to interval- and graded exercise tests. This was based upon post-exercise systemic increases in pro-inflammatory cytokine transcripts, decreases in circulating nitric oxide (NO), and peak heart rate response. The second study showed increases in interfereron-gamma, interleukin-1 beta, and interleukin-10 cytokine transcripts, upregulated antioxidant defenses (SOD, total glutathione, glutathione peroxidase), and a decline in plasma NO, following intense exercise. Supplemental SOD (3000 IU/d for 6 wks) had no detectable influence on markers of performance, inflammatory response, or antioxidant status relative to intense exercise, and compared to the placebo control. The third study showed that repeated arthrocentesis in the same joint did not alter synovial fluid concentrations of prostaglandin E2 (PGE2), although anabolic cartilage metabolism, measured by chondroitin sulfate-846 (CS), was elevated at the last sample, indicating sensitivity to repeated synovial fluid aspiration. Following exercise, increases in PGE2 relative to pre-exercise concentrations, and transient increases in CS, indicated healthy adaptive responses to exercise. Similar to the second study, supplemental SOD had no influence on PGE2 or CS, suggesting it was not an effective solution for reducing exercise-induced inflammation or improving antioxidant status in horses. These studies contribute to a limited working knowledge of inflammatory and antioxidant responses to intense exercise, and may be useful when differentiating between adaptive responses and early pathological changes resulting from exercise-induced stress in horses.
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electronic resource
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xiv, 181 p. : ill.
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Ph.D.
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Includes bibliographical references
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by Emily Dawn Lamprecht
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Lamprecht
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Emily Dawn
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1980-
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Emily Dawn Lamprecht
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Williams
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Carey
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chair
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Carey A. Williams
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Bagnell
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Carol
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co-chair
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Carol A. Bagnell
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John-Alder
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Henry
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Henry B. John-Alder
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Horohov
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David
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David W. Horohov
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Sue
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Sue A. Shapses
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Rutgers University
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Graduate School - New Brunswick
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2010
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2010-01
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xx
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Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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doi:10.7282/T3765FFF
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ETD doctoral
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The author owns the copyright to this work.
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Copyright protected
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Open
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Lamprecht
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Emily
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2010-01-06 18:14:07
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Emily Lamprecht
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Rutgers University. Graduate School - New Brunswick
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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