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Learning increases the survival of newborn neurons provided that learning is difficult to achieve and successful
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Learning increases the survival of newborn neurons provided that learning is difficult to achieve and successful
Identifier
ETD_2633
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000053034
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Psychology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Neurons--Growth
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Paired-association learning
Abstract
(type = abstract)
Processes of learning can increase the survival of new neurons generated in the adult hippocampal formation (Gould et al., 1999; Shors, 2009). However, only some types of learning are effective. Recent studies demonstrate that animals that learn the conditioned response (CR), but require more trials to do so, rescue more new neurons than animals that quickly acquire the CR, or those that fail to acquire the CR. These studies altered task parameters to modify the number of trials required to learn a conditioned response. Here we asked whether pharmacological manipulations that decrease or increase learning would decrease and increase, respectively, the number of cells that remain in the hippocampus after training. To answer this question, we first prevented learning with the competitive NMDA receptor antagonist (±)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP). Administration of the NMDA receptor antagonist CPP each day before training prevented acquisition of the trace eyeblink response, and the subsequent increase in neuronal survival. Second, we facilitated learning with the cognitive enhancer d-cycloserine (DCS), a compound that increases NMDA receptor activity via its actions at the glycine binding site. Administration of the NMDA receptor partial agonist DCS each day before training increased the number of learned responses and the number of cells that survived. Animals that successfully acquired the CR early in training possessed more cells than those exposed to unpaired stimuli but those that learned later in training retained even more newborn neurons. DCS & CPP did not alter performance or cell number when administered after training. These results demonstrate that NMDA receptor activation modifies learning and as a consequence, alters the number of surviving neurons in the hippocampus. Moreover, they demonstrate that associative learning increases neuronal survival provided that the learning is both difficult to achieve and successful .
PhysicalDescription
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electronic resource
Extent
vi, 34 p. : ill.
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application/pdf
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text/xml
Note
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M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
Includes abstract
Note
(type = statement of responsibility)
by Daniel M. Curlik II
Name
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Curlik, II
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Daniel
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author
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Daniel Curlik, II
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NamePart
(type = family)
Shors
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(type = given)
Tracey J
Role
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chair
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Advisory Committee
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Tracey J Shors
Name
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(type = personal)
NamePart
(type = family)
Otto
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(type = given)
Timothy
Role
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internal member
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Advisory Committee
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Timothy Otto
Name
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NamePart
(type = family)
Matzel
NamePart
(type = given)
Louis
Role
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(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Louis Matzel
Name
(ID = NAME-1);
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME-2);
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NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010
Place
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xx
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
(type = doi)
doi:10.7282/T39W0FKV
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Curlik, II
GivenName
Daniel
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-04-15 12:53:39
AssociatedEntity
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(AUTHORITY = rulib)
Role
Copyright holder
Name
Daniel Curlik, II
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
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(AUTHORITY = rulib)
Type
License
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
(ID = RE-2);
(AUTHORITY = rulib)
Type
Embargo
DateTime
2010-05-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after November 30th, 2010.
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Technical
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ETD
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application/pdf
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application/x-tar
FileSize
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542720
Checksum
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