RUcore: Rutgers University Community Repository
A rat model of fetal alcohol syndrome
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
A rat model of fetal alcohol syndrome
SubTitle
molecular and behavioral analysis
Identifier
ETD_2548
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000053119
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Microbiology and Molecular Genetics
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Fetal alcohol syndrome
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Alcoholism in pregnancy--Complications
Abstract
(type = abstract)
The maternal consumption of alcohol during pregnancy produces a wide range of abnormalities in the offspring. The main purpose of this thesis is to investigate the (1) effects of prenatal ethanol exposure in two types of animal behavioral models and (2) effects on gene expression patterns produced by prenatal ethanol exposure. Sprague-Dawley rats from fetal alcohol exposure (FAE) and pair-fed (PF) treatment groups were tested as young adults. The purpose of the first study is to assess the effects of prenatal ethanol exposure on anxiety and social behaviors. The elevated plus maze model is used to measure anxiety and the social interaction model is used to study social activity in an open-field. Based on previous literature, we hypothesize that prenatal ethanol exposure will result in a significant difference in activity on the elevated plus maze and open-field. However, our data from the behavioral tests do not show a robust difference between the prenatally exposed and the pair-fed animals. There are no significant effects of prenatal ethanol exposure on the open versus closed arms of the plus maze. There are also no significant effects of prenatal ethanol exposure on social interaction with a companion rat. A reason for the subtle differences between the two behavioral tests is likely due to handling prior to the testing manipulations. The purpose of the second study is to see the effects of prenatal ethanol exposure on gene expression. We hypothesize that FAE significantly affects gene expression, and using gene profiling techniques, we examine the patterns of gene expression in control and treated populations. In our study, we analyze gene expression profiles with pathway analysis as the approach. We identify specific molecular pathways that are significantly impacted by prenatal alcohol exposure. We further extend this study by focusing on the long-term potentiation (LTP) pathway and examine multiple molecular components in this pathway for their gene expression levels. LTP has long been known to be the mechanism by which memories are formed and stored. According to our study, it is compelling to say that FAE can cause profound and long-lasting alterations in the cellular signaling mechanisms associated with activity-dependent synaptic plasticity and memory formation. Our gene expression data also indicate an opposing pattern of ethanol effect on LTP pathway in the hippocampus and hypothalamus.
PhysicalDescription
Form
(authority = gmd)
electronic resource
Extent
x, 78 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note
(type = degree)
M.S.
Note
Includes abstract
Note
Includes bibliographical references
Note
(type = statement of responsibility)
by Truc N. Luu
Name
(ID = NAME-1);
(type = personal)
NamePart
(type = family)
Luu
NamePart
(type = given)
Truc N.
NamePart
(type = date)
1985-
Role
RoleTerm
(authority = RULIB)
author
DisplayForm
Truc Luu
Name
(ID = NAME-2);
(type = personal)
NamePart
(type = family)
Yu
NamePart
(type = given)
Lei
Role
RoleTerm
(authority = RULIB)
chair
Affiliation
Advisory Committee
DisplayForm
Lei Yu
Name
(ID = NAME-3);
(type = personal)
NamePart
(type = family)
St. John
NamePart
(type = given)
Ann
Role
RoleTerm
(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Ann St. John
Name
(ID = NAME-4);
(type = personal)
NamePart
(type = family)
Tomie
NamePart
(type = given)
Arthur
Role
RoleTerm
(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Arthur Tomie
Name
(ID = NAME-5);
(type = personal)
NamePart
(type = family)
Sheldon
NamePart
(type = given)
Michael
Role
RoleTerm
(authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Michael Sheldon
Name
(ID = NAME-1);
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME-2);
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010
Place
PlaceTerm
(type = code)
xx
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T34B31DQ
Genre
(authority = ExL-Esploro)
ETD graduate
Back to the top
Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Luu
GivenName
Truc
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-04-07 17:27:45
AssociatedEntity
(ID = AE-1);
(AUTHORITY = rulib)
Role
Copyright holder
Name
Truc Luu
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
(ID = AO-1);
(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Back to the top
Technical
ContentModel
ETD
MimeType
(TYPE = file)
application/pdf
MimeType
(TYPE = container)
application/x-tar
FileSize
(UNIT = bytes)
716800
Checksum
(METHOD = SHA1)
130c4eac3135e96b7922bb5ef409251af48efecf
Back to the top
Statistical Profile