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RNA structure analysis via the rigid block model
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
RNA structure analysis via the rigid block model
Identifier
ETD_2994
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056321
Language
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(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
RNA
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
RNA--Metabolism
Abstract
RNA structure is at the forefront of our understanding of the origin of life, and the mechanisms of life regulation and control. RNA plays a primordial role in some viruses. Our knowledge of the importance of RNA in cellular regulation is relatively new, and this knowledge, along with the detailed structural elucidation of the transcription machine, the ribosome, has propelled interest in understanding RNA to a level which starts to closely resemble that given to proteins and DNA. In the process of progressively understanding the landscape of functionality of such a complex polymer as RNA, one practical task left to the structural chemist is to understand the details of how structure relates to large-scale polymer processes. With this in mind the fundamental problems which fuel the work described in this thesis are those of the conformations which RNA’s assume in nature, and the aim to understand how RNA folds. The RNA folding problem can be understood as a mechanical problem. Therefore efforts to determine its solution are not foreign to the use of statistical mechanical methods combined with detailed knowledge of atomic level structure. Such methodology is mainly used in this work in a long-term effort to understand the intrinsic structural features of RNA, and how they might relate to its folding.
PhysicalDescription
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electronic resource
Extent
xxiv, 133 p. : ill.
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application/pdf
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Note
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Ph.D.
Note
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Includes bibliographical references
Note
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Includes vita
Note
(type = statement of responsibility)
by Mauricio Esguerra Neira
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Esguerra
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Mauricio Esguerra
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1972-
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author
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Mauricio Esguerra
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Olson
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Wilma K
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chair
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Advisory Committee
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Wilma K Olson
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(type = family)
Berman
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Helen
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internal member
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Advisory Committee
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Helen Berman
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(type = family)
Levy
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(type = given)
Ronald
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internal member
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Advisory Committee
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Ronald Levy
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Pilch
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Daniel S
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outside member
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Advisory Committee
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Daniel S Pilch
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
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(type = degree)
2010-10
Place
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(type = code)
xx
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD
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(type = host)
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T39P31F5
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
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(type = personal)
Name
FamilyName
Esguerra
GivenName
Mauricio
Role
Copyright Holder
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Type
Permission or license
DateTime
2010-10-07 12:09:51
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Mauricio Esguerra
Affiliation
Rutgers University. Graduate School - New Brunswick
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
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ETD
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application/x-tar
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15206400
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