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Epigenetic methylation and its implication in cancer and neurodegeneration
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Epigenetic methylation and its implication in cancer and neurodegeneration
Identifier
ETD_2922
Identifier
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http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056726
Language
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eng
Genre
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theses
Subject
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(authority = RUETD)
Topic
Cell and Developmental Biology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Cytology
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Gene expression
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Cancer--Gene therapy
Subject
(ID = SBJ-5);
(authority = ETD-LCSH)
Topic
Nervous system--Degeneration
Abstract
(type = abstract)
Epigenetics has become a fast-growing area of study in cellular biology. An epigenetic trait is defined as a stably inherited phenotype resulting from changes in a chromosome without alterations in the DNA sequence (1). These types of modifications are essential for normal cellular function, assisting in the activation or repression of necessary genes in various stages of development. There are instances, though, in which the modifications can be altered to induce irregular gene transcription. In these cases, the results can provoke various forms of disease. In mammals, epigenetic methylation has been found to play an important part in all forms of cancer, with two key areas of alteration. These are the specific methylation of sequences of DNA, as well as modifications on the histones surrounding DNA. Since the discovery of their involvement in the change of gene expression, histone modifications and DNA methylation have been implicated in diseases other than cancer, such as neurological disorders including schizophrenia and Alzheimer’s disease. One very important aspect of epigenetic methylation is its reversibility. This key property has created a promising field of epigenetic therapy, which has led to the development of several FDA approved drugs for cancer treatment. It has also generated several new and exciting ideas for future paths of treatment.
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electronic resource
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viii, 57 p. : ill.
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M.S.
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Includes bibliographical references
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by Terence J. Purdon
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Purdon
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Terence J.
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Terence Purdon
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Kusch
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Thomas
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chair
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Thomas Kusch
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Fong
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Dunne
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internal member
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Dunne Fong
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Martin
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Charles
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Charles Martin
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Sheldon
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Michael
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outside member
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Advisory Committee
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Michael Sheldon
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated
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2010
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2010-10
Place
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xx
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T39C6X6T
Genre
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ETD graduate
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Rights
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Name
FamilyName
Purdon
GivenName
Terence
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Type
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DateTime
2010-09-28 06:37:11
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Terence Purdon
Affiliation
Rutgers University. Graduate School - New Brunswick
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
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ETD
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808960
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