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The actions of IGFBPs on growth and glucose metabolism in transgenic mouse models
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
The actions of IGFBPs on growth and glucose metabolism in transgenic mouse models
Identifier
ETD_2713
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056728
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Neuroscience
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Glucose--Metabolism
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Insulin--Receptors
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Repressors, Genetic
Subject
(ID = SBJ-5);
(authority = ETD-LCSH)
Topic
Mice--Growth
Subject
(ID = SBJ-6);
(authority = ETD-LCSH)
Topic
Mice as laboratory animals
Abstract
(type = abstract)
The roles of insulin/IGF signaling in growth control and glucose metabolism have been extensively studied. To date, the growth inhibitory effects of IGFBPs and impaired glucose homeostasis caused by IGFBP-3 have been mostly studied in vitro. Our study, here, provides the first in vivo evidence by targeted gene deletion to show that IGFBP-2, -3, and -5 have inhibitory effects on growth, whereas IGFBP-4 and -6 have no effect. However, only male IGFBP-3 KO mice have increased body weight, indicating a gender difference in the system. IGFBP-4 mice, in either C57BL/6J or 129S6 background, show no difference from wild type animals. Disrupting the ternary complex of IGF/IGFBP by knocking out IGFBP-3 and -5 at the same time has a tremendous effect in growth of female mice. As a result, double KO mice gain even more weight than single IGFBP-3 or -5 KO mice. Disruption of the most abundant IGFBP-3 in circulation results in enhanced glucose tolerance companied by increased insulin secretion and insulin sensitivity. This makes IGFBP-3 a potential target in treating obesity and type 2 diabetes. Lastly, the effect of IGFBPs in traumatic brain injury was studied and it shows that, following brain injury, IGFBP-2 mRNA expression is upregulated at the injury site with the consequence that IGFBP-2 KO mice have significantly increased neurogenesis around the subventricular zone (SVZ). The role of IGFBP-2 in proliferation of stem cells in the CNS is further confirmed by quantitative PCR which shows a 28-fold upregulation in cultured neurospheres from the postnatal brain compared to Stratagene’s Universal Mouse Reference cDNA.
PhysicalDescription
Form
(authority = gmd)
electronic resource
Extent
ix, 60 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Mei Qin
Name
(ID = NAME-1);
(type = personal)
NamePart
(type = family)
Qin
NamePart
(type = given)
Mei
Role
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author
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Mei Qin
Name
(ID = NAME-2);
(type = personal)
NamePart
(type = family)
Pintar
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(type = given)
John
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(authority = RULIB)
chair
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Advisory Committee
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John Pintar
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(type = personal)
NamePart
(type = family)
Driscol
NamePart
(type = given)
Monica
Role
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(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Monica Driscol
Name
(ID = NAME-4);
(type = personal)
NamePart
(type = family)
Zhou
NamePart
(type = given)
Renping
Role
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(authority = RULIB)
internal member
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Advisory Committee
DisplayForm
Renping Zhou
Name
(ID = NAME-5);
(type = personal)
NamePart
(type = family)
Driscoll
NamePart
(type = given)
Monica
Role
RoleTerm
(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Monica Driscoll
Name
(ID = NAME-1);
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME-2);
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NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010-10
Place
PlaceTerm
(type = code)
xx
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3JS9Q5B
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Qin
GivenName
Mei
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-05-10 12:41:56
AssociatedEntity
(ID = AE-1);
(AUTHORITY = rulib)
Role
Copyright holder
Name
Mei Qin
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
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(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
ContentModel
ETD
MimeType
(TYPE = file)
application/pdf
MimeType
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application/x-tar
FileSize
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1054720
Checksum
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9ea2c9fc19cbe29ff761f446a8bf08c9e9888c06
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