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Amphetamine's dose-dependent effects on dorsolateral striatum sensorimotor neuron firing
Descriptive
TitleInfo
Title
Amphetamine's dose-dependent effects on dorsolateral striatum sensorimotor neuron firing
Name
(type = personal)
NamePart
(type = family)
Ma
NamePart
(type = given)
Sisi
NamePart
(type = date)
1985-
DisplayForm
Sisi Ma
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
West
NamePart
(type = given)
Mark O
DisplayForm
Mark O West
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Kusnecov
NamePart
(type = given)
Alexander W
DisplayForm
Alexander W Kusnecov
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Wagner
NamePart
(type = given)
George C
DisplayForm
George C Wagner
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2011
DateOther
(qualifier = exact);
(type = degree)
2011-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Dorsolateral striatum neurons were extracellularly recorded in awake behaving rats to examine amphetamine’s effects. On one hand, amphetamine has been shown to elicit motoric changes through increasing neurotransmitters such as dopamine and serotonin in the central nervous system. On the other hand, dorsolateral striatum is highly involved in motoric function and contains abundant neurotransmitter transporters that amphetamine could act upon. Therefore, it has been hypothesized that dorsolateral striatum medium spiny neurons play a role in amphetamine’s effects on motoric behavior. Although many studies have supported a role of the striatum, the involvement of its individual neurons has not been adequately characterized. Therefore, the neuronal activities of single neurons that correlate with vertical head movements in dorsolateral striatum were simultaneously recorded with head movement behavior before and after acute amphetamine injection to test the hypothesis. Behaviorally, it was observed that amphetamine induced head movements across all doses administered. Lower doses (1mg/kg and 2 mg/kg) induced more numbers of longer movements than the higher dose (4 mg/kg). Neuronally, firing of individual head movement neurons during similar head movements defined by direction, distance, duration, velocity and apex were compared before and after administration of amphetamine. Analysis revealed that the change of firing rate induced by amphetamine was co-determined by the dose administered and the baseline firing rate of the neuron. More specifically, for all doses administered, amphetamine increased the firing rate of the slower firing neurons, but decreased the firing rate of the faster firing neurons. The magnitudes of the enhancement and reduction were greater at lower doses (1mg/kg and 2 mg/kg), but were less pronounced at the high dose (4mg/kg) of amphetamine. The parallel changes of behavior and firing pattern of dorsolateral striatum neurons support the hypothesis that dorsolateral striatum neurons participate in mediating the motor behavioral effects induced by amphetamine.
Subject
(authority = RUETD)
Topic
Psychology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_3603
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
viii, 54 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Sisi Ma
Subject
(authority = ETD-LCSH)
Topic
Amphetamines
Subject
(authority = ETD-LCSH)
Topic
Rats—Effect of drugs on
Subject
(authority = ETD-LCSH)
Topic
Motor neurons
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063525
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
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(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T34748Z4
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Ma
GivenName
Sisi
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2011-09-27 14:14:54
AssociatedEntity
Name
Sisi Ma
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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1767936
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windows xp
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application/pdf
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1771520
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