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Potential effects of triterpenoids in osteoarthritis model systems

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TitleInfo
Title
Potential effects of triterpenoids in osteoarthritis model systems
Name (type = personal)
NamePart (type = family)
Shah
NamePart (type = given)
Noopur Snehal
NamePart (type = date)
1987-
DisplayForm
Noopur Shah
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Suh
NamePart (type = given)
Nanjoo
DisplayForm
Nanjoo Suh
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Conney
NamePart (type = given)
Allan H
DisplayForm
Allan H Conney
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Liu
NamePart (type = given)
Alice
DisplayForm
Alice Liu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Osteoarthritis, a degenerative joint disease, is one of the most common rheumatic disorders and the leading cause of chronic disability in the United States. Currently there are many pharmacologic and non-pharmacologic therapies for osteoarthritis however; these therapies do not appear to concomitantly affect disease symptoms and structure. Here, we have investigated the effects of synthetic oleanane triterpenoids, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), and its analogs CDDO-imidazolide (CDDOIm) and CDDO-ethyl amide (CDDO-EA) in the anabolic as well as catabolic pathways of osteoarthritis using two different osteoarthritis model systems. We found that CDDO-Im and CDDO-EA, at concentrations as low as 200 nM, induce chondrogenesis in organ cultures of new born mouse calvaria in a time and dose dependant manner. The cartilage phenotype was measured histologically with metachromatic toluidine blue staining for proteoglycans and by immunohistochemical staining for type II collagen. Real time PCR analysis using mRNA from calvaria after a 7day treatment with CDDO-Im and CDDO-EA showed upregulation of SOX9 and collagen type 2 and well as other cartilage markers. We also found that LG100268, a rexinoid, downregulates the expression of primary cartilage markers in mouse calvaria suggesting a possible role for rexinoids in chondrogenesis. Vitamin D (1α 25(OH)2 D3) did not show any significant effects at the dose tested. With respect to the catabolic pathway, we established that CDDO-EA and CDDO-Im are involved in suppression of tumor necrosis factor-α (TNF-α) and interleukin 1-β (IL-1β) induced matrix metalloproteinase (MMP) expression in SW1353 chondrosarcoma cells. These results suggest that synthetic triterpenoids CDDO-Im and CDDO-EA can be considered as potentially useful agents for the treatment of osteoarthritis.
Subject (authority = RUETD)
Topic
Cell and Developmental Biology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_3968
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
ix, 115 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Noopur Snehal Shah
Subject (authority = ETD-LCSH)
Topic
Osteoarthritis--Treatment
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065264
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T32J69SJ
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Shah
GivenName
Noopur
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-04-15 21:01:58
AssociatedEntity
Name
Noopur Shah
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2498048
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application/pdf
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application/x-tar
FileSize (UNIT = bytes)
2498560
Checksum (METHOD = SHA1)
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