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Interfacial interactions of nanoparticles with surfactants and polymers

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TitleInfo
Title
Interfacial interactions of nanoparticles with surfactants and polymers
SubTitle
a computational approach to target biomedical and pharmaceutical systems
Name (type = personal)
NamePart (type = family)
Tomasini
NamePart (type = given)
Michael D.
NamePart (type = date)
1982-
DisplayForm
Michael Tomasini
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Tomassone
NamePart (type = given)
Silvina
DisplayForm
Silvina Tomassone
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Moghe
NamePart (type = given)
Prabhas
DisplayForm
Prabhas Moghe
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Muzzio
NamePart (type = given)
Fernando
DisplayForm
Fernando Muzzio
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Shapley
NamePart (type = given)
Nina
DisplayForm
Nina Shapley
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-05
CopyrightDate (qualifier = exact)
2012
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Nanotechnology is an emerging field with the promise for new materials and applications, particularly in the medical field for diagnosis and treatment of disease. The high surface area to volume ratio of nanoparticles gives rise to useful material properties such as enhanced solubility and dissolution for drug nanoparticles as well as superparamagnetism in the case of magnetic nanoparticles. Often, nanoparticle interactions with surfactants and polymers arise in a variety of scenarios: the production and stabilization to reduce particle agglomeration, to aid in nanoparticle delivery to specific areas of the body, increase bioavailability by avoiding body clearance mechanisms, add desired functionality, and finally the biological targets of nanoparticles are often the surfactants (lipids of the cell membrane) or polymers (proteins) of the body. Understanding the interfacial interactions of nanoparticles with polymers or surfactants is therefore crucial in proceeding ahead with nanoparticles as viable options for medical treatments. In this dissertation, a series of computational techniques are employed to elucidate the interfacial interactions at the molecular level between surfactants, polymers, ii and nanoparticles in three different case studies. First, Molecular Dynamics and Dissipative Particle Dynamics simulation methods are used to study the stability of a model cell membrane to an applied stress in order to mimic the interactions that occur in magnetic fluid hyperthermia, a nanoparticle-based treatment for cancerous tumors. Here, the aim is to determine if magnetic nanoparticles are capable of generating mechanical forces sufficient to rupture a cell membrane. Secondly, coarse-grained Molecular Dynamics is utilized to explore the interaction of micelle-forming amphiphilic molecules interacting with the human scavenger receptor A for use in preventing uptake of oxidized low-density lipoproteins. Finally, Monte Carlo simulations are developed to study nanocrystal nucleation from solution in the presence of polymers to determine factors that act to promote or inhibit nucleation. iii
Subject (authority = RUETD)
Topic
Biomedical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4002
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xiv, 147 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Michael D. Tomasini
Subject (authority = ETD-LCSH)
Topic
Nanoparticles
Subject (authority = ETD-LCSH)
Topic
Nanotechnology
Subject (authority = ETD-LCSH)
Topic
Nanomedicine
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065282
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3BZ6506
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Tomasini
GivenName
Michael
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-04-16 16:22:37
AssociatedEntity
Name
Michael Tomasini
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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