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The effects of Wnt5a and Wnt3a and PCP signaling on Schwann cell biology and myelination
Descriptive
TitleInfo
Title
The effects of Wnt5a and Wnt3a and PCP signaling on Schwann cell biology and myelination
Name
(type = personal)
NamePart
(type = family)
Jani
NamePart
(type = given)
Neha
NamePart
(type = date)
1988-
DisplayForm
Neha Jani
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Maurel
NamePart
(type = given)
Patrice
DisplayForm
Patrice Maurel
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Gao
NamePart
(type = given)
Nan
DisplayForm
Nan Gao
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Melendez-Vasquez
NamePart
(type = given)
Carmen
DisplayForm
Carmen Melendez-Vasquez
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Planar cell polarity (PCP) is known as the polarization of cells within the plane of the tissue layer. This form of polarization controls several epithelial and non-epithelial morphological processes, such as the orientation of primary cilia in the inner ear, convergent extension (CE) and directed migration. A three tiered model of PCP regulation has been proposed which consists of the global, core, and effector modules. However there is one addition level of modulation through non-canonical Wnt signaling pathway. Of the many Wnt proteins a few have been identified to signal primarily through this pathway. One such protein is Wnt5a, which has been shown to modulate PCP during directed cell migration. In this study we gather preliminary data for the presence of PCP signaling components in Schwann cells and investigate the effect of Wnt5a and its antagonist Wnt3a on Schwann cell proliferation, migration and myelination.
Subject
(authority = RUETD)
Topic
Biology
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4343
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
iii, 63 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Neha Jani
Subject
(authority = ETD-LCSH)
Topic
Cytology--Research
Subject
(authority = ETD-LCSH)
Topic
Myelination
Subject
(authority = ETD-LCSH)
Topic
Cell receptors
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000066552
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Location
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(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3XK8DC8
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Jani
GivenName
Neha
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-10-01 12:53:27
AssociatedEntity
Name
Neha Jani
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
FileSize
(UNIT = bytes)
3121664
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windows xp
ContentModel
ETD
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application/pdf
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application/x-tar
FileSize
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3123200
Checksum
(METHOD = SHA1)
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