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Incorporation of curcumin in lipid based delivery systems and assessment of its bioaccessibility
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TitleInfo
Title
Incorporation of curcumin in lipid based delivery systems and assessment of its bioaccessibility
Name
(type = personal)
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(type = family)
Solanki
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(type = given)
Kavitakumari
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(type = date)
1987-
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Kavitakumari Solanki
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author
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QINGRONG
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QINGRONG HUANG
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Advisory Committee
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chair
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Ludescher
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Richard
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Richard Ludescher
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Advisory Committee
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internal member
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Takhistov
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(type = given)
Paul
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Paul Takhistov
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Advisory Committee
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internal member
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Rutgers University
Role
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degree grantor
Name
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Graduate School - New Brunswick
Role
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school
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Text
Genre
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theses
OriginInfo
DateCreated
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2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Subject
(authority = RUETD)
Topic
Food Science
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD_4321
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electronic resource
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application/pdf
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text/xml
Extent
xvi, 75 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Kavitakumari H. Solanki
Subject
(authority = ETD-LCSH)
Topic
Turmeric--Health aspects
Subject
(authority = ETD-LCSH)
Topic
Functional foods
Identifier
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http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066992
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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doi:10.7282/T3WD3Z92
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ETD graduate
Abstract
Curcumin, the major curcuminoid compound from turmeric (Curcuma longa) is a well-studied nutraceutical with many health promoting biological properties. The benefits of curcumin greatly dependon its solubilization (bioaccessibility) and subsequent absorption through cell lining so that it can reach systemic/general circulation. Unfortunately, curcumin has low water solubility and undergoes rapid metabolism on oral delivery.
Lipids have shown to affect the absorption of poorly soluble nutraceuticals such as curcumin by enhancing solubilization in the intestinal milieu through alterations to the composition and character of the colloidal environment –e.g. vesicles, mixed micelles and micelles when delivered orally. Thus, the purpose ofthis study was to formulate threelipid-based delivery systems with curcuminoids –gel like emulsions, nanoemulsions andorganogels, and investigate their impact on in vitro solubilization or bioaccessibility.
Curcumin was dissolved in MC T oil with the help of Span 20 to be used as the lipid phase. Gel-like emulsions, nanoemulsions andorganogelswere then formulated using the curcumin-MCT oil lipid phase using different types of sugar esters as organogelators and emulsifiers. The organogels and gel-like emulsions are viscoelastic in naturewith a solid dominant behaviorwhich was supported by the rheological data. Optical and fluorescence microscopic imaging helped understand the morphology ofcurcumin inthe lipidbased delivery systemsas well as the systems themselves. Digital scanning calorimetry was used to study the phase transitionsthat occurin the systems. The bioaccessibilityof the different lipid based delivery systemswas evaluated using in vitrolipolysis experiments (dynamic pH stat lipid digestion model). Results suggest that lipid based delivery systems have more bioaccessibility when compared to that of unformulated curcuminoids. The bioaccessibility of curcumin increased at least 6.4 folds when it was incorporated in a lipid based delivery system as compared to unformulated curcuminoids.O ut of the three systems tested, gel-like emulsions had the highest stability and thus can be good candidate for incorporation and delivery of curcumin.
Lipids have shown to affect the absorption of poorly soluble nutraceuticals such as curcumin by enhancing solubilization in the intestinal milieu through alterations to the composition and character of the colloidal environment –e.g. vesicles, mixed micelles and micelles when delivered orally. Thus, the purpose ofthis study was to formulate threelipid-based delivery systems with curcuminoids –gel like emulsions, nanoemulsions andorganogels, and investigate their impact on in vitro solubilization or bioaccessibility.
Curcumin was dissolved in MC T oil with the help of Span 20 to be used as the lipid phase. Gel-like emulsions, nanoemulsions andorganogelswere then formulated using the curcumin-MCT oil lipid phase using different types of sugar esters as organogelators and emulsifiers. The organogels and gel-like emulsions are viscoelastic in naturewith a solid dominant behaviorwhich was supported by the rheological data. Optical and fluorescence microscopic imaging helped understand the morphology ofcurcumin inthe lipidbased delivery systemsas well as the systems themselves. Digital scanning calorimetry was used to study the phase transitionsthat occurin the systems. The bioaccessibilityof the different lipid based delivery systemswas evaluated using in vitrolipolysis experiments (dynamic pH stat lipid digestion model). Results suggest that lipid based delivery systems have more bioaccessibility when compared to that of unformulated curcuminoids. The bioaccessibility of curcumin increased at least 6.4 folds when it was incorporated in a lipid based delivery system as compared to unformulated curcuminoids.O ut of the three systems tested, gel-like emulsions had the highest stability and thus can be good candidate for incorporation and delivery of curcumin.
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Rights
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The author owns the copyright to this work.
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Name
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Solanki
GivenName
Kavitakumari
Role
Copyright Holder
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Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2012-09-28 12:44:28
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Name
Kavitakumari Solanki
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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License
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Open
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Permission or license
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