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Ecological correlates of genetic diversity in Borrelia burgdorferi, the Lyme disease bacterium
Descriptive
TitleInfo
Title
Ecological correlates of genetic diversity in Borrelia burgdorferi, the Lyme disease bacterium
Name
(type = personal)
NamePart
(type = family)
Vuong
NamePart
(type = given)
Holly B
NamePart
(type = date)
1979-
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Holly Vuong
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(authority = RULIB)
author
Name
(type = personal)
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(type = family)
Morin
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(type = given)
Peter J
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Peter J Morin
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Advisory Committee
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chair
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(type = family)
Ostfeld
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(type = given)
Richard S
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Richard S Ostfeld
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Advisory Committee
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(authority = RULIB)
co-chair
Name
(type = personal)
NamePart
(type = family)
Smouse
NamePart
(type = given)
Peter
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Peter Smouse
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Fonseca
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(type = given)
Dina
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Dina Fonseca
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Brisson
NamePart
(type = given)
Dustin
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Dustin Brisson
Affiliation
Advisory Committee
Role
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(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
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Text
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theses
OriginInfo
DateCreated
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2012
DateOther
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(type = degree)
2012-10
Place
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xx
Language
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(type = code)
eng
Abstract
(type = abstract)
Lyme disease is the number one reported vector-borne disease in the United States, and this disease continues to spread in the Northeast and Midwest. Lyme disease is caused by Borrelia burgdorferi, a bacterium that circulates among vertebrate host species and transmitted among hosts by the black-legged tick (Ixodes scapularis). The bacterium has high genetic variation at the outer surface protein C (ospC) locus, and past studies suggests that hosts act as ecological niches to the ospC genotypes. In particular, five types are known to be human invasive (HIS), making it essential to examine disease risk at the genotypic level. My studies focus on understanding the ecological drivers of ospC diversity and frequency profile at the individual, community, and landscape scales. In chapter one, I found that endemic areas of New York State have higher ospC richness and diversity than newly invaded areas, and that HIS types are relatively common across the landscape. There is high turnover of genotypes from one population to another population along the invasion scale. In chapter two, host community composition matters when examining ospC diversity, and that host composition and host diversity are important in predicting HIS infection prevalence. Contrasting important predictors between years 2006 and 2009 could be a result of annual variation and/or site variation, since the majority of sites were not sampled in both years. Obtaining better inclusive host community composition and diversity estimates could help with the predictive powers of these metrics on the ospC frequency profile, especially with HIS types. In chapter three, variation among nine host species and their associated ospC genotype frequency profiles supports the host-niche concept. Short-tailed shrews (Blarina brevicauda) and American robins (Turdus migratorius) have high proportions of HIS to non-HIS, suggesting they could help contribute to higher disease risk. Lastly, there is support for a trade-off between occurrence frequency and transmission efficiencies of ospC types from hosts to ticks feeding on these individuals. This research sheds new light on how host composition and diversity influences disease risk, that HIS types infect all nine host species, and that HIS types occur commonly across NY State.
Subject
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Topic
Ecology and Evolution
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Title
Rutgers University Electronic Theses and Dissertations
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Identifier
ETD_4357
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electronic resource
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application/pdf
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text/xml
Extent
xi, 118 p. : ill.
Note
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Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Holly B Vuong
Subject
(authority = ETD-LCSH)
Topic
Borrelia burgdorferi--New York (State)
Subject
(authority = ETD-LCSH)
Topic
Lyme disease--New York (State)
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000067012
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T3PC314F
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Vuong
GivenName
Holly
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2012-10-02 11:53:23
AssociatedEntity
Name
Holly Vuong
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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564224
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573440
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