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Dopaminergic sensitivity in the prefrontal cortex is associated with variations in general cognitive abilities and is a target for working memory training

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TitleInfo
Title
Dopaminergic sensitivity in the prefrontal cortex is associated with variations in general cognitive abilities and is a target for working memory training
TitleInfo (type = alternative)
Title
Dopamine signaling and general cognitive abilities
Name (type = personal)
NamePart (type = family)
Wass
NamePart (type = given)
Christopher David
NamePart (type = date)
1985-
DisplayForm
Christopher Wass
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Matzel
NamePart (type = given)
Louis D
DisplayForm
Louis D Matzel
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Otto
NamePart (type = given)
Timothy
DisplayForm
Timothy Otto
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Kusnecov
NamePart (type = given)
Alexander
DisplayForm
Alexander Kusnecov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2012
DateOther (qualifier = exact); (type = degree)
2012-10
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
An individual’s performance across diverse tests of cognitive ability tends to co-vary, indicative of a common source of underlying variance (i.e., "general intelligence"). Recent evidence indicates that the processing efficacy of working memory predicts the level of general intelligence in humans and general cognitive abilities (GCA) in non-human animals (e.g. rodents and monkeys). One component of working memory, namely selective attention, has been reported to highly co-vary with general intelligence, and evidence suggests that dopamine D1 signaling in the medial prefrontal cortex (mPFC) critically modulates attentional abilities. Here, we characterized the GCA of 48 CD-1 outbred mice based on their aggregate performance across five diverse tests of learning. Using immunohistochemical techniques following administration of a D1 agonist (SKF82958, 1 mg/kg), we examined the relationship between GCA and endogenous sensitivity of D1 receptors in the mPFC, the dlPFC, and the striatum. Results indicate a differential sensitivity of D1 receptors in the mPFC (but not the dlPFC or striatum) between animals of high GCA and low GCA (quantified by cFos activation in response to the D1 agonist). In Experiment 2, we assessed whether the enhancement in D1 receptor sensitivity levels were the result of an increased amount of D1 receptors in the mPFC. Results indicated that animals of high GCA and low GCA express no differences in the density of D1 receptors in the mPFC. Subsequently we examined whether the imposition of a working memory training regimen (with a high demand on selective attention) modulates the same dopaminergic signaling mechanisms that were associated with innate GCA. Working memory training promoted an increase in animals’ GCA and enhanced the sensitivity of D1 receptors in the mPFC. These findings suggest that the sensitivity (but not number) of D1 receptors in the mPFC may both regulate GCA and may be a target for working memory training that promotes GCA.
Subject (authority = RUETD)
Topic
Psychology
Subject (authority = ETD-LCSH)
Topic
General factor (Psychology)
Subject (authority = ETD-LCSH)
Topic
Short-term memory
Subject (authority = ETD-LCSH)
Topic
Cognition
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4307
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vii, 35 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Christopher David Wass
Subject (authority = ETD-LCSH)
Topic
Dopaminergic neurons
Subject (authority = ETD-LCSH)
Topic
Prefrontal cortex
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000067017
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3T43RVC
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Wass
GivenName
Christopher
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2012-09-27 13:59:47
AssociatedEntity
Name
Christopher Wass
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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