DescriptionWalking from place to place requires route planning. Past studies have shown that animal and human navigators tend to go directly towards their goal despite environmental constraints such as obvious obstacles. The current study investigated route planning in small indoor spaces that involved stopping at multiple destinations in a pre-determined sequence. In three sets of experiments, participants walked in a small room to reach two to three temporary stopping points. In Experiment 1, we investigated the effect of later destinations on participants’ route choices towards the first and second destinations. The results support our hypothesis that, when choosing between symmetric two routes of the same length, participants would show a clear bias towards the route that deviate the least from the direction of their final, or, goal destination. In Experiment 2, we screened participants’ view of most of the room and indicated the location of later destinations on a map. Results showed that the effect of subsequent destinations on participants’ route choice to immediate destinations was reduced. In Experiment 3, we used a different method to hide subsequent destinations and provided participants with an up-side down map. With up-side down diagrams showing the location of the destinations, the result showed no effect of later destinations on participants’ route choice to go the first and the second destinations. The results showed that ultimate destinations affect route choice to intermediate destinations and this effect is greatest when the ultimate destination is visible. Results of this study can be applied to environmental design such as arranging multiple events for a conference. Organizers should consider the location of the events that occur at the same time in order to balance traffic flow through the pathway spaces.