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Regulation of synaptic transmission by cytoplasmic ATM

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TitleInfo
Title
Regulation of synaptic transmission by cytoplasmic ATM
Name (type = personal)
NamePart (type = family)
Han
NamePart (type = given)
Yu Ray
NamePart (type = date)
1975-
DisplayForm
YU HAN
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Plummer
NamePart (type = given)
Mark R.
DisplayForm
Mark R. Plummer
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Herrup
NamePart (type = given)
Karl
DisplayForm
Karl Herrup
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Hsu
NamePart (type = given)
Shu C.
DisplayForm
Shu C. Hsu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Kusnecov
NamePart (type = given)
Alexander
DisplayForm
Alexander Kusnecov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Li
NamePart (type = given)
Hedong
DisplayForm
Hedong Li
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Ataxia-telangiectasia (A-T) is a devastating childhood disorder caused by mutation of the ataxia-telangiectasia mutated gene (ATM) which encodes a member of the PI3 kinase family. In most cells, ATM is localized in the nucleus and is involved in DNA damage repair. In neurons, however, a substantial fraction of ATM is cytoplasmic, and the function of this cytoplasmic pool is poorly understood and not well studied. Since likely binding partners of ATM include the molecules synapsin-I and VAMP2, we examined the possibility that cytoplasmic ATM is a regulator of synaptic plasticity. FM4-64 dye tracing experiment showed a deficit of spontaneous vesicle releasing in ATM deficient cells. Hippocampal slice recordings revealed that Shaffer collateral long-term potentiation (LTP) in homozygous Atmtm1Awb mice was significantly reduced comparing to wild-type controls. In Atmtm1Awb mutant mice, ATM protein is still made, but is a novel, catalytically less active, splice mutant product. By comparison in Atmtm1Bal mutant mice in which the protein is not made, short-term plasticity such as synaptic fatigue and paired-pulse facilitation were compromised, whereas LTP was less affected. Binding studies show that cytoplasmic ATM serves as a scaffold that brings together ATR, synapsin-I and VAMP2. This observation suggests that cytoplasmic ATM in the Atmtm1Awb mice may be acting to disable the complex, whereas the simple absence of ATM is less disruptive. The next stage of this work will focus on understanding the mechanism of how cytoplasmic ATM is involved in synaptic function.
Subject (authority = RUETD)
Topic
Neuroscience
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4684
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
x, 92 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Yu Ray Han
Subject (authority = ETD-LCSH)
Topic
Ataxia telangiectasia in children
Subject (authority = ETD-LCSH)
Topic
Genetic disorders in children
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068874
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3DR2T3F
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
HAN
GivenName
YU
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-04-14 22:32:18
AssociatedEntity
Name
YU HAN
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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