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The protective effect of a diet rich in fish oil in an amphetamine toxicity model of Parkinson’s disease
Descriptive
TitleInfo
Title
The protective effect of a diet rich in fish oil in an amphetamine toxicity model of Parkinson’s disease
Name
(type = personal)
NamePart
(type = family)
Medvecky
NamePart
(type = given)
Christopher M.
NamePart
(type = date)
1986-
DisplayForm
Christopher Medvecky
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
George
NamePart
(type = given)
Wagner C
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Wagner C George
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Alexander
NamePart
(type = given)
Kusnecov
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Kusnecov Alexander
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Tracey
NamePart
(type = given)
Shors
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Shors Tracey
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Yao-Ping
NamePart
(type = given)
Lu
DisplayForm
Lu Yao-Ping
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2013
DateOther
(qualifier = exact);
(type = degree)
2013-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Parkinson’s disease is a neurodegenerative disorder that damages the dopaminergic neurons of the substantia nigra and their axonal projections to the striatum. This cell death results in significant motor deficits that include muscular rigidity, resting tremor, and akinesia. Although there is no known cure for Parkinson’s disease, evidence from epidemiological studies suggests that consumption of fish oil, which is rich in omega-3 polyunsaturated fatty acids (PUFAs), may help to reduce the risk of this debilitating disorder. Furthermore, research using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) models of Parkinson’s disease supports this conclusion. Consequently, this dissertation examined the potential protective effect of fish oil in an amphetamine-toxicity model of Parkinson’s disease. In Experiment 1, mice were administered a diet rich in either corn oil or fish oil for one week and then were treated with either amphetamine or saline. After sacrifice 72 hours later, striatal tissue was assayed for neurochemical content using HPLC. It was determined that fish oil protects against amphetamine-induced depletions of dopamine and its metabolites. Given the role of oxidative stress in amphetamine toxicity, this protection may be a result of the antioxidant properties of fish oil. Experiment 2, in addition to successfully replicating this effect, extended the protective effect of fish oil to behavioral and physiological measures. More specifically, a diet rich in fish oil significantly altered amphetamine’s impact on behaviors including oral dyskinesia, self biting, stereotypy, and backwards walking; it also mitigated amphetamine-induced changes in dermal temperature. These results suggest that fish oil can moderate the elevated dopaminergic activity caused by amphetamine administration. Experiment 3 was designed to examine the time course of protection afforded by the fish oil-rich diet, and it was discovered that the protective effect of fish oil develops between 1 and 3 days of consumption. Experiment 4 was performed to determine if fish oil alters amphetamine-induced increases in oxidative stress and dopamine release. Fish oil did not impact these measures, indicating that other mechanisms may be responsible for the observed protection. Collectively, these findings indicate that the consumption of fish oil offers protection against amphetamine toxicity in a model of Parkinson’s disease.
Subject
(authority = RUETD)
Topic
Psychology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4637
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vii, 107 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Christopher M. Medvecky
Subject
(authority = ETD-LCSH)
Topic
Parkinson's disease--Alternative treatment
Subject
(authority = ETD-LCSH)
Topic
Fish oils--Research
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068914
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3B27SWQ
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Medvecky
GivenName
Christopher
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2013-04-11 13:26:08
AssociatedEntity
Name
Christopher Medvecky
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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