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Behavioral and physiological assessment of an animal model of post-traumatic stress disorder
Descriptive
TitleInfo
Title
Behavioral and physiological assessment of an animal model of post-traumatic stress disorder
Name
(type = personal)
NamePart
(type = family)
Goswami
NamePart
(type = given)
Sonal
NamePart
(type = date)
1983-
DisplayForm
Sonal Goswami
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Abercrombie
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(type = given)
Elizabeth
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Elizabeth Abercrombie
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Advisory Committee
Role
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chair
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(type = personal)
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(type = family)
Pare
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(type = given)
Denis
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Denis Pare
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
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(type = family)
Pang
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(type = given)
Kevin
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Kevin Pang
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Advisory Committee
Role
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(authority = RULIB)
internal member
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(type = personal)
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(type = family)
Tepper
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(type = given)
James
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James Tepper
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Milad
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(type = given)
Mohammed
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Mohammed Milad
Affiliation
Advisory Committee
Role
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outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - Newark
Role
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school
TypeOfResource
Text
Genre
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theses
Genre
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ETD doctoral
OriginInfo
DateCreated
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2013
DateOther
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(type = degree)
2013-10
Place
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xx
Language
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(type = code)
eng
Abstract
(type = abstract)
Post-traumatic stress disorder (PTSD) is an anxiety disorder triggered by exposure to a traumatic event. Despite recent progress, the causes and pathophysiology of PTSD remain poorly understood, partly because of ethical limitations inherent to human studies. One approach to circumvent this obstacle is to study PTSD in a valid animal model of the human syndrome. In one such model, extreme and long-lasting behavioral manifestations of anxiety develop in a subset of Lewis rats after exposure to an intense predator threat (PT) that mimics the type of life-or-death situation known to precipitate PTSD in humans. Thus, the first half of this thesis tested whether the Lewis rat model reproduces salient features of human PTSD. The results of these studies established the model’s face validity. The second half of this thesis used this model to identify alterations in the physiological properties of amygdala neurons that underlie the expression of PTSD. These studies revealed that PTSD is associated with differences in the synaptic responsiveness of central amygdala (CeA) neurons. Overall, these results suggest that the Lewis rat model of PTSD can be used to gain mechanistic insights in the pathophysiology of PTSD.
Subject
(authority = RUETD)
Topic
Neuroscience
Subject
(authority = ETD-LCSH)
Topic
Post-traumatic stress disorder--Animal models
Subject
(authority = ETD-LCSH)
Topic
Post-traumatic stress disorder--Treatment
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
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TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Identifier
ETD_4866
Identifier
(type = doi)
doi:10.7282/T3QC01G3
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
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text/xml
Extent
xvi, 132 p. : ill.
Note
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Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Sonal Goswami
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Goswami
GivenName
Sonal
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2013-05-30 01:02:12
AssociatedEntity
Name
Sonal Goswami
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Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ETD
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windows xp
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