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Functional organization of the bed nucleus of the stria terminalis
Descriptive
TitleInfo
Title
Functional organization of the bed nucleus of the stria terminalis
Name
(type = personal)
NamePart
(type = family)
Nagy
NamePart
(type = given)
Frank
NamePart
(type = date)
1976-
DisplayForm
Frank Nagy
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Krekelberg
NamePart
(type = given)
Bart
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Bart Krekelberg
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Zaborszky
NamePart
(type = given)
Laszlo
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Laszlo Zaborszky
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Morrell
NamePart
(type = given)
Joan
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Joan Morrell
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Pare
NamePart
(type = given)
Denis
DisplayForm
Denis Pare
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Lang
NamePart
(type = given)
Eric J
DisplayForm
Eric J Lang
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2013
DateOther
(qualifier = exact);
(type = degree)
2013-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
This thesis examined the functional organization of the bed nucleus of the stria terminalis (BNST), a poorly known brain region. Two series of experiments were performed. First, in anesthetized rats, we compared antidromic response latencies in anterior BNST (BNSTa) and central amygdala (CeA) neurons to brainstem stimuli. The frequency distribution of latencies was unimodal in BNSTa neurons (~10 ms) and bimodal in CeA cells (~10 and ~30 ms). After stria terminalis (ST) lesions, only short-latency antidromic responses were observed. Since BNST and CeA share excitatory basolateral amygdala (BL) inputs, lengthening the path of CeA axons might allow synchronization of BNSTa and CeA impulses to brainstem when activated by BL inputs. Consistent with this, the latency difference between CeA and BNSTa neurons to BL stimuli approximated that seen between the antidromic responses of BNSTa cells and CeA neurons with long-conduction times. These results point to a hitherto unsuspected level of temporal coordination between CeA and BNSTa neurons, supporting the idea of shared functions. Second, in behaving rats, we recorded BNST neurons in anterolateral (BNST-AL) and anteromedial (BNST-AM) regions under spontaneous conditions and during auditory fear conditioning. The firing rates of BNST- AL and AM neurons were highest in paradoxical sleep, lowest during slow-wave sleep and intermediate during wakefulness. During habituation, most neurons were unresponsive to the conditioned stimulus (CS). After fear conditioning, many BNST-AL neurons developed inhibitory responses to the CS whereas in BNST- AM, neurons with positive CS responses prevailed. The behavior of BNST-AM and AL neurons during contextual fear paralleled their CS responsiveness: BNST-AM neurons fired at higher rates during contextual freezing than movement whereas BNST-AL cells did the opposite. However, in contrast with cued fear where similar proportions of BNST- AM and AL neurons were CS responsive, many more BNST-AM than AL neurons showed differential activity in relation to contextual freezing. These findings point to regional differences in the activity of BNST-AL and AM in relation to learned fear, raising the possibility that they exert opposite influences on fear output networks. The stronger recruitment of BNST-AM neurons during contextual relative to cued fear may account for BNST’s selective involvement in the former.
Subject
(authority = RUETD)
Topic
Neuroscience, Integrative
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_5040
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xiv, 107 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Frank Nagy
Subject
(authority = ETD-LCSH)
Topic
Brain--Anatomy
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3HM56F5
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Nagy
GivenName
Frank
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2013-09-24 16:29:50
AssociatedEntity
Name
Frank Nagy
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2013-10-31
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = end)
2014-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
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windows xp
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