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Vitamin D ultraviolet radiation and disparities
Descriptive
TitleInfo
Title
Vitamin D ultraviolet radiation and disparities
SubTitle
survival and multiple primary cancers in colorectal and prostate patients
Name
(type = personal)
NamePart
(type = family)
Abruzzi
NamePart
(type = given)
Amy E.
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Amy Abruzzi
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(authority = RULIB)
author
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(type = personal)
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(type = family)
DEMISSIE
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(type = given)
KITAW
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KITAW DEMISSIE
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Advisory Committee
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chair
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(type = family)
RHOADS
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GEORGE
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GEORGE RHOADS
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Advisory Committee
Role
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internal member
Name
(type = personal)
NamePart
(type = family)
Ohman-Strickland
NamePart
(type = given)
Pamela
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Pamela Ohman-Strickland
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
August
NamePart
(type = given)
David
DisplayForm
David August
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2013
DateOther
(qualifier = exact);
(type = degree)
2013-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Vitamin D, a steroid hormone with documented anti-cancer properties, is largely obtained through environmental exposure. It has been suggested that vitamin D deficiency, which is higher among U.S. Blacks than Whites, may contribute to survival differences from prostate and colorectal cancers. In addition, Blacks may be at higher risk for Multiple Primary Cancers (MPCs) involving these tumor pairings. It is currently unknown what factors other than prior radiotherapy may contribute to MPC development. The aims of this thesis were to: (1) conduct a systematic review of vitamin D radiation (VDR) and its relationship to prostate and colorectal cancers, including the role of the environment, sun-reactive Skin Types and their correlation with race/ethnicity; (2) examine whether Black/White differences in survival are related to VDR, and if higher levels of VDR are associated with increased survival from prostate and colorectal cancers; and (3) examine if Black/White disparities exit in MPC development for these cancers and if lower levels of VDR are associated with these disparities. Using a retrospective, population-based cohort design, male patients aged 50 years and older who were diagnosed from 1978 to 2003 with a non-metastatic first primary prostate, colon or rectal cancer were followed for 10 year survival and MPC development. VDR levels were estimated based on the patient’s county of residency at diagnosis. In addition to tumor factors, socio-demographic covariates such as county-level socio-economic deprivation and a proxy for smoking were included. The analysis utilized a multivariate Cox Proportional Hazards model, adjusted for various factors, and an evaluation of competing risks. The results indicate that VDR may contribute to Black-White differences in survival from prostate and colon cancer, which is strongly modified by urbanicity. While a moderate protective association was observed with increasing VDR among patients residing in all-urban areas, a modest increase in risk was observed among patients in least-urban areas. To a lesser extent, VDR may also contribute to an increased risk of some MPCs. More generally, Blacks are at higher risk for MPCs and several factors including prior radiotherapy, smoking and socio-economic deprivation may increase the risk of their development.
Subject
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Topic
Public Health
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_5129
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xii, 181 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Amy E. Abruzzi
Subject
(authority = ETD-LCSH)
Topic
Vitamin D deficiency
Subject
(authority = ETD-LCSH)
Topic
Vitamin D in the body
Subject
(authority = ETD-LCSH)
Topic
Cancer--Longitudinal studies
Subject
(authority = ETD-LCSH)
Topic
Prostate--Cancer--Etiology
Subject
(authority = ETD-LCSH)
Topic
Colon--Cancer--Etiology
Subject
(authority = ETD-LCSH)
Topic
Rectal--Cancer--Etiology
Subject
(authority = ETD-LCSH)
Topic
Mortality and race
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3HH6H29
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Abruzzi
GivenName
Amy
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2013-10-02 11:15:37
AssociatedEntity
Name
Amy Abruzzi
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2013-10-31
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = end)
2014-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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Statistical Profile