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The effect of cholesterol on the stability of a DPPC-cholesterol bilayer
Descriptive
TitleInfo
Title
The effect of cholesterol on the stability of a DPPC-cholesterol bilayer
Name
(type = personal)
NamePart
(type = family)
Muralidharan
NamePart
(type = given)
Bharatram
NamePart
(type = date)
1989-
DisplayForm
Bharatram Muralidharan
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Dutt
NamePart
(type = given)
Meenakshi
DisplayForm
Meenakshi Dutt
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Chiew
NamePart
(type = given)
Yee
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Yee Chiew
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Roth
NamePart
(type = given)
Charlie
DisplayForm
Charlie Roth
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2013
DateOther
(qualifier = exact);
(type = degree)
2013-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Cholesterol plays a very important part in regulating the properties of mixed phospholipid bilayers. In a human cell, about 50% is covered in cholesterol, and is becoming increasingly important to understand the interactions between cholesterol and the lipid in maintaining properties of the membrane, and in particular its stability more clearly. In an age of increased computer dependence, simulation models based on basic interaction parameters could prove pivotal in advancements in fields such as nano-medicine or monitoring the effect of viruses on cells. In this thesis, a mesoscopic model system of Dipalmitoylphosphatidylcholine (DPPC)-Cholesterol and water, is used to mimic a typical biological membrane. The equilibrium conformation of a membrane requires a tensionless state of the membrane. Depending on the tension, a membrane could either stretch or fold (compression). Simulations using Dissipative Particle Dynamics were used and the concentration of cholesterol was varied and the resulting tension was observed.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_5074
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
viii, 56 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Bharatram Muralidharan
Subject
(authority = ETD-LCSH)
Topic
Bilayer lipid membranes
Subject
(authority = ETD-LCSH)
Topic
Cholesterol
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3XW4GTH
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Muralidharan
GivenName
Bharatram
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2013-09-27 23:46:11
AssociatedEntity
Name
Bharatram Muralidharan
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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