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Physiological, anatomical, and behavioral investigations on the bed nucleus of the stria terminalis
Descriptive
TitleInfo
Title
Physiological, anatomical, and behavioral investigations on the bed nucleus of the stria terminalis
Name
(type = personal)
NamePart
(type = family)
Rodríguez-Sierra
NamePart
(type = given)
Olga E.
NamePart
(type = date)
1978-
DisplayForm
Olga Rodríguez Sierra
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Krekelberg
NamePart
(type = given)
Bart
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Bart Krekelberg
Affiliation
Advisory Committee
Role
RoleTerm
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chair
Name
(type = personal)
NamePart
(type = family)
Paré
NamePart
(type = given)
Denis
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Denis Paré
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Golowasch
NamePart
(type = given)
Jorge
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Jorge Golowasch
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Myers
NamePart
(type = given)
Catherine
DisplayForm
Catherine Myers
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Hammack
NamePart
(type = given)
Sayamwong
DisplayForm
Sayamwong Hammack
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - Newark
Role
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school
TypeOfResource
Text
Genre
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theses
Genre
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ETD doctoral
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-01
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The anterior part of the bed nucleus of the stria terminalis (BNST-A) has emerged as a critical structure mediating fear and anxiety-like behavior. It is strategically situated to integrate information from limbic forebrain regions such as the amygdala, prefrontal cortex and hippocampus; and influence major fear and stress output effectors. Previous pharmacobehavioral studies have assumed that the BNST is a homogeneous structure despite the fact that anatomical studies contradict this assumption. The work presented in this thesis aimed to systematically examine the functional organization of BNST-A and its relation to anxiety-like behavior. In the first chapter, I examined the electroresponsive and morphological properties of BNST-A neurons. I showed that there are two dominant BNST-A cell types intermingled with at least other three less numerous cell types. In the second chapter, I investigated the intrinsic connections of BNST-A with the use of glutamate uncaging (GU). Overall, GU usually elicited inhibitory postsynaptic potentials and the incidence of intraregional connections was higher than interregional links. Lastly, I investigated the physiological properties of BNST-A neurons in a rat model of post-traumatic stress disorder. I show that neurons in BNST-A regions exhibit opposing alterations in synaptic responsiveness, supporting the idea that BNST-A is physiologically heterogeneous, with some regions exerting anxiolytic and others anxiogenic influences.
Subject
(authority = RUETD)
Topic
Neuroscience
Subject
(authority = ETD-LCSH)
Topic
Fear
Subject
(authority = ETD-LCSH)
Topic
Anxiety
Subject
(authority = ETD-LCSH)
Topic
Neurosciences
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Identifier
ETD_5205
Identifier
(type = doi)
doi:10.7282/T32N50C3
PhysicalDescription
Form
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xvii, 148 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Olga E. Rodríguez-Sierra
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Rodríguez Sierra
GivenName
Olga
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2013-12-13 12:10:58
AssociatedEntity
Name
Olga Rodríguez Sierra
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2014-01-31
DateTime
(encoding = w3cdtf);
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(point = end)
2015-01-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 31st, 2015.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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Statistical Profile