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Non-invasive access to the vagus nerve and its projections in humans
Descriptive
TitleInfo
Title
Non-invasive access to the vagus nerve and its projections in humans
SubTitle
FMRI evidence
Name
(type = personal)
NamePart
(type = family)
Frangos
NamePart
(type = given)
Eleni
NamePart
(type = date)
1985-
DisplayForm
Eleni Frangos
Role
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(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Komisaruk
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Barry R.
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Barry R. Komisaruk
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Advisory Committee
Role
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chair
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(type = family)
Hanson
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(type = given)
Stephen J.
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Stephen J. Hanson
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Advisory Committee
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internal member
Name
(type = personal)
NamePart
(type = family)
LoBue
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(type = given)
Vanessa
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Vanessa LoBue
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Zaborszky
NamePart
(type = given)
Laszlo
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Laszlo Zaborszky
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = personal)
NamePart
(type = family)
Ellrich
NamePart
(type = given)
Jens
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Jens Ellrich
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - Newark
Role
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school
TypeOfResource
Text
Genre
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theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The vagus nerve -- the main visceral nerve -- has a somatosensory auricular branch that innervates the external ear. The central projections of the auricular branch of the vagus nerve have not been reported on in humans. Therefore, the focus of this dissertation is to ascertain whether electrical stimulation of the external ear, in the sensory field of the auricular branch of the vagus nerve, activates the “classical” visceral vagus central projection sites in healthy men and women, and to characterize the regional brain activity elicited by cymba conchae stimulation. Mild electrical stimulation of the vagal sensory field in the cymba conchae of the left external ear activated “classical” vagal central projections, including the nucleus of the solitary tract, spinal trigeminal nucleus, parabrachial area, dorsal raphe, locus coeruleus, amygdala, and nucleus accumbens. Activation of the paracentral lobule of the cerebral cortex was also observed. Deactivations in response to the stimulation were observed in the hippocampus and hypothalamus. The activity within many of these areas was found to persist even after cessation of stimulation. Furthermore, there is a marked effect on the network among these areas during cymba conchae stimulation and after stimulation. These findings provide evidence that the central projections of the vagus nerve can be accessed non-invasively via the external ear in humans. The findings suggest a rational basis for the observed therapeutic anti-nociceptive, anti-depressive, and anti-convulsive effects of vagal stimulation.
Subject
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Topic
Psychology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_5622
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xvi, 117 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Eleni Frangos
Subject
(authority = ETD-LCSH)
Topic
Vagus nerve
Subject
(authority = ETD-LCSH)
Topic
Labyrinth (Ear)
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
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rucore10002600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3G73BZP
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Frangos
GivenName
Eleni
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2014-04-30 20:15:34
AssociatedEntity
Name
Eleni Frangos
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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