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Gas phase studies of organic and biological species using mass spectrometry
Descriptive
TitleInfo
Title
Gas phase studies of organic and biological species using mass spectrometry
Name
(type = personal)
NamePart
(type = family)
Chen
NamePart
(type = given)
Mu
NamePart
(type = date)
1985-
DisplayForm
Mu Chen
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Lee
NamePart
(type = given)
Jeehiun K.
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Jeehiun K. Lee
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Warmuth
NamePart
(type = given)
Ralf
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Ralf Warmuth
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Krogh-Jespersen
NamePart
(type = given)
Karsten
DisplayForm
Karsten Krogh-Jespersen
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Buckley
NamePart
(type = given)
Brian
DisplayForm
Brian Buckley
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
This dissertation focuses on the study of gas phase properties of several organic and bioorganic species, using experimental (mass spectrometry) and computational (Gaussian) methods. Damaged nucleobases are from oxidation or methylation of normal nucleobases. These damaged bases are linked with diseases, aging, and cell death. They can be excised by enzymes such as DNA glycosylases. However the mechanism is still unknown. Tautomerism, proton affinity, and acidity of a damaged base xanthine have been studied to understand the mechanism of AlkA, the enzyme that excises xanthine. 1,2,3-triazoles are novel compounds that have various applications, especially in synthetic and catalytic chemistry. The fundamental properties of these triazoles could potentially be useful in understanding their binding to metals. Tautomerism, proton affinity, and acidity of several 1,2,3-triazoles have been studied by using computational and experimental methods. The results indicate that PA of the triazoles correlate with their binding ability to metals such as gold. N-Heterocyclic carbenes (NHCs) are good electron donors and are used as ligands in organometallic complexes. However, unlike the traditional carbenes (methylene), NHCs are not electrophilic. N,N’-Diamidocarbenes (DACs) display not only nucleophilic but also electrophilic properties. The proton affinity of several DACs were studied and found to be close to proton affinity of the NHCs. The electrophilic reactivities of DACs can be attributed to their low-lying LUMO orbitals. Nucleophilicity and electrophilicity in the gas phase are important reactivity parameters of organic species. Gas phase calculations and experiments can exclude the influence of solvents and reveal the intrinsic properties of nucleophiles and electrophiles. Classic physical organic approaches, including Hammett plots, kinetic isotope effect, and H/D exchange, have been employed to study the gas phase reactions between nucleophiles and electrophiles. RNA oligonucleotides (2-5nt) are found to play important roles in the transcription of DNA. However, the specific RNA species and their sequences are unknown. An LC-MS method has been developed for the separation and quantification of these oligonucleotides. Collision induced dissociation (CID) patterns of the oligonucleotides are found to be useful in the characterization of these biologically significant species.
Subject
(authority = RUETD)
Topic
Chemistry and Chemical Biology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_5511
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xv, 100 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Mu Chen
Subject
(authority = ETD-LCSH)
Topic
Mass spectrometry
Subject
(authority = ETD-LCSH)
Topic
Gas dynamics
Subject
(authority = ETD-LCSH)
Topic
Gas research
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T37942Z8
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Chen
GivenName
Mu
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-04-15 00:41:14
AssociatedEntity
Name
Mu Chen
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2014-05-31
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = end)
2016-05-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 30th, 2016.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
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windows xp
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