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Neural mechanisms of actions of transcranial electrical stimulation
Descriptive
TitleInfo
Title
Neural mechanisms of actions of transcranial electrical stimulation
Name
(type = personal)
NamePart
(type = family)
Kar
NamePart
(type = given)
Kohitij
NamePart
(type = date)
1985-
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Kohitij Kar
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author
Name
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Pare
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Denis
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Denis Pare
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Advisory Committee
Role
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chair
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Krekelberg
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Bart
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Bart Krekelberg
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Advisory Committee
Role
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internal member
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(type = personal)
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(type = family)
Tepper
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(type = given)
James
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James Tepper
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Nadim
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(type = given)
Farzan
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Farzan Nadim
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Sommer
NamePart
(type = given)
Marc
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Marc Sommer
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Advisory Committee
Role
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(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - Newark
Role
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school
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Text
Genre
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theses
Genre
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ETD doctoral
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DateCreated
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2014
DateOther
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(type = degree)
2015-01
CopyrightDate
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2014
Place
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xx
Language
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(type = code)
eng
Abstract
(type = artist's description)
There is considerable evidence for clinical and behavioral efficacy of transcranial electrical stimulation (tES). The effects range from suppressing Parkinsonian tremors to augmenting human learning and memory. Despite widespread use, the neurobiological mechanisms of action of tES on the intact human brain are unclear. In the work presented in this thesis, I have taken a multi-methodological approach to probe tES mechanisms. First, I studied the electric field spread induced by the application of tES, behaviorally. Second, I examined the behavioral effects of tES on human motion perception. I observed that tES (10 Hz, 0.5 mA) applied over area hMT+ (a brain area specialized in processing visual motion) attenuates motion adaptation. This result led to the hypothesis that tES-induced membrane voltage modulations reduce adaptation in motion-selective neurons. Finally, I tested this hypothesis by directly measuring tES-induced neural activity changes in a homologous area in the macaque brain (area MT). Tuning curve estimates of macaque MT neurons showed that tES attenuated the effects of visual motion adaptation on tuning amplitude and width. In addition to single cell measures, tES also significantly modified the evoked local field potentials. The results provide novel insights into how tES interacts with neural activity and establishes the awake, behaving macaque as an in-vivo animal model to study tES mechanisms.
Subject
(authority = RUETD)
Topic
Neuroscience
Subject
(authority = ETD-LCSH)
Topic
Brain stimulation--Therapeutic use
Subject
(authority = ETD-LCSH)
Topic
Electric stimulation
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD
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(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Identifier
ETD_6104
Identifier
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doi:10.7282/T34M9664
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (x, 123 p. : ill.)
Note
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Ph.D.
Note
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Includes bibliographical references
Note
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Includes vita
Note
(type = statement of responsibility)
by Kohitij Kar
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Kar
GivenName
Kohitij
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2014-12-22 15:58:55
AssociatedEntity
Name
Kohitij Kar
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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2015-01-31
DateTime
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2015-08-02
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after August 2nd, 2015.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ETD
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windows xp
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Statistical Profile