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Tumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy
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Savla, Ronak. Tumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy. Retrieved from https://doi.org/doi:10.7282/T3KS6T83

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TitleTumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy
NameSavla, Ronak (author); Minko, Tamara (chair); You, Guofeng (internal member); Kagan, Leonid (internal member); He, Huixin (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2015
Other Date2015-01 (degree)
SubjectPharmaceutical Science, Nanoparticles, Cancer--Treatment, Tumors
Extent1 online resource (xiv, 202 p. : ill.)
DescriptionCancer is one of the most insidious diseases. Compromising of over 100 different types and sharing the unifying factors of uncontrolled growth and metastasis, unmet clinical needs in terms of cancer diagnosis and treatment continue to exist. It is widely accepted that most forms of cancer are treatable or even curable if detected before widespread metastasis occurs. Nearly a quarter of deaths in the United States is the result of cancer and it only trails heart disease in terms of annual mortality. Surgery, chemotherapy, and radiation therapy are the primary treatment modalities for cancer. Research in these procedures has resulted in substantial benefits for cancer patients, but there is still room for an improvement. However, a time has been reached at which it appears that the benefits from these modalities have been reached the maximum. Therefore, it is vital to develop new strategies for the diagnosis and treatment of cancer. The field of nanotechnology is concerned with structures in the nanometer size range and holds the potential to drastically impact and improve the lives of patients suffering from cancer. Not only can nanotechnology improve current methods of diagnosis and treatment, it has a possibility of introducing newer and better modalities. The overall purpose of this work is to develop novel nanotechnology-based methodologies for the diagnosis and treatment of various forms of cancers. The first aim of the project is the development of a multifunctional targeted nanosystem for the delivery of siRNA to overcome drug resistance. The second aspect is the synthesis of a quantum dot-based delivery system that releases drug in response to pH changes. The third aim is the development of a targeted, tumor environment responsive magnetic resonance nanoparticle contrast agent coupled with a nanoparticle-based treatment.
NotePh.D.
NoteIncludes bibliographical references
Noteby Ronak Savla
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3KS6T83
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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