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Computational design of bio-inspired vesicles and their interactions with nanoparticles using coarse-grained models
Descriptive
TitleInfo
Title
Computational design of bio-inspired vesicles and their interactions with nanoparticles using coarse-grained models
Name
(type = personal)
NamePart
(type = family)
Aydin
NamePart
(type = given)
Fikret
NamePart
(type = date)
1987-
DisplayForm
Fikret Aydin
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Dutt
NamePart
(type = given)
Meenakshi
DisplayForm
Meenakshi Dutt
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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school
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Text
Genre
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theses
OriginInfo
DateCreated
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2015
DateOther
(qualifier = exact);
(type = degree)
2015-10
CopyrightDate
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(qualifier = exact)
2015
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
One of the key challenges in the design of self-assembled nanostructured materials as delivery vehicles is the prediction of their resultant shape and size as well as controlling their interactions with various nanoparticles and macromolecules while optimizing their circulation time and biodistribution profile. In order to overcome the challenges behind the optimal design of such nanostructured soft materials, the mesoscopic properties of soft biomaterials such as cell membranes or liposomes need to be investigated. Fundamental insight into the morphology and dynamics of these materials will require the development and utilization of a suite of modeling tools with each class of tools tuned to address physical phenomena over a specific spatio-temporal scale. These multiple modeling techniques have to be interfaced at the juncture of two scales to enable a multiscale resolution of the system behavior over large length (from 1 nm up to 1 µm) and time scales (nano-seconds to micro-seconds). The aim of this work to understand the underlying mechanisms that affect the organization, shape, stiffness and interfacial stability of biomaterials, and furthermore investigate the cooperative relations among them which dictate their final structural and functional state. Understanding these fundamental processes can help developing simple models of stable bio-inspired membranes and vesicles with tunable phase segregation properties as well as desirable stiffness and shape characteristics for various applications such as the design and prediction of novel hybrid soft materials for encapsulation and delivery of therapeutic agents, cellular sensing and sustainability. It will also contribute to understanding the underlying mechanisms of the interactions between micelles, proteins or synthetic particles with bio-inspired multi-component membranes, or liposomal drug delivery vehicles.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_6748
PhysicalDescription
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(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxii, 140 p. : ill.)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Nanoparticles
Subject
(authority = ETD-LCSH)
Topic
Bilayer lipid membranes
Note
(type = statement of responsibility)
by Fikret Aydin
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3W097W4
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Aydin
GivenName
Fikret
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2015-09-18 07:55:43
AssociatedEntity
Name
Fikret Aydin
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
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windows xp
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