DescriptionRationale: With 25% global disease burden and only 3% global health workforce, the African region continues to account for the largest proportion of people living with HIV. While HIV task sharing between physicians and nurses, improved access to antiretroviral treatment, it led to African nurses acquiring roles beyond their traditional scope of practice. Numerous patient outcome research have identified the benefits of task sharing but research on nurse-related outcomes remains limited. This study attempts to fill the gap in knowledge by examining the demographic and setting correlates of self-efficacy and job satisfaction among Nigerian nurses in HIV task sharing roles. Method: A pilot study was conducted using a focus group of ten expert nurses to ascertain the content validity and appropriateness of the study instruments. In the main study, 508 nurses in task sharing roles from 8 of 36 states in Nigeria were surveyed. Result: A total of 399 surveys from tertiary (26%), secondary (46%) and primary (28%) facilities met criteria for analyses. The mean age and years in nursing practice were 42 (SD = 9.1) and 17 (SD = 9.2); 86% worked in Government hospitals, 76% were female and 70% Registered Nurse/Midwives. Over 95% received training and mentoring and 82% had previous HIV nursing experience. Self-Efficacy for task sharing had statistically significant correlation with female gender but negatively correlated with years in nursing practice. Job Satisfaction was statistically correlated with years in nursing practice; dual licensure as Nurse/Midwife; working in tertiary hospital; older age; male gender; duration of training and being mentored. Longer HIV nursing experience and working in secondary and primary health centers were found to increase the likelihood for job dissatisfaction. Conclusion: Although more than 95% of the nurses received WHO recommended training and mentoring, they still faced system related challenges which negatively affected job satisfaction. Similar to reports in literature, these findings have critical implications for burnout, retention and quality service delivery. System-specific strategies such as: complementary staffing mix; continuing education; certification; updated policies, guidelines, scope of practice and curriculum that reflect current professional practice are needed to support nurses in expanded roles.