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theses

Lung cancer occurrences are more likely as compared to any other type of cancer in the world with very high mortality rate. Based on the past research, smoking and family history of smoking are the most common causes of lung cancer by per age, race and gender. Lung cancer is the second deadliest cancer in this world after prostate cancer and breast cancer. In this research, we have used the Nationwide Inpatient Sample Data from the year 2003 to 2007 to analyze current and predict future trend of lung cancer. Towards the analyses, we have included all the anatomical sub categories of lung to determine, which lobe of lung is having considerably higher risk of catching cancer. Our anatomical analysis concludes the risk occurrence of lung cancer follows an order from high to low: Upper lobe, Lower lobe, Other-parts of the lung, Main bronchus, and Middle lobe. We have also examined the association of each category of lung with race across the gender. The overall lung cancer analysis indicates, White American and Black have the higher risk of getting lung cancer as compared with other races. Further analysis of individual lobe of lung denotes, among the all races, White American is more susceptible to each lobe of lung except other-parts of lung. The odds ratio analysis for individual anatomical site concludes white male and female [odds ratio of all sub category- male/female 1.03 to 1.08] are equally susceptible to each lobe of lung. The black females [odds ratio of Lower lobe-male/female 1.08] are highly associated with lower lobe of lung cancer as compared with black males. Whereas Hispanic, Asian and Native American females are more associated with middle lobe lung cancer as compared with Hispanic, Asian and native American males [odds ratio for middle lobe - male/female 0.89 to 0.95]. Based on the past research, smoking is the primary cause of the death in the lung cancer by age, race and gender. In this research, we have used National Impatient Sample and census population for the state CA, Fl, TX, NY, IL, RI, VA, SC, and WI to determine the association of geographical variation with the risk factors by population. We have confirmed that incidence of lung cancer cases in CA (bigger state by population) is lower than RI and VA (smaller state by population). In other word, we confirmed our hypothesis that higher population, need not have to have higher incidence rate (In this research, incidence rate refers to discharged), but other factors like race, gender, pollution, exposure to chemical factor also play an important role to measure susceptibility of the occurrences. This research study was limited to the National Inpatient database across the United State. Lung cancer patients were extracted base on principle diagnosis of the lung cancer symptoms.

ETD_7315

doi:10.7282/T3DV1N14

Ph.D.

Includes bibliographical references

by Riddhi. J. Vyas

ETD doctoral

The author owns the copyright to this work.