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Characterization of alternative anti-diabetic compounds from Moringa oleifera
Descriptive
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Title
Characterization of alternative anti-diabetic compounds from Moringa oleifera
Name
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Gachomo
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Bryan
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Bryan Gachomo
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author
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Martin
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Joseph
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Joseph Martin
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Advisory Committee
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chair
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Rutgers University
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degree grantor
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Camden Graduate School
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school
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theses
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2016
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2016-05
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2016
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xx
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eng
Abstract
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Diabetes mellitus is a growing health challenge across the world affecting millions of people particularly in developing nations. There are two main forms of diabetes: Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). T2D is the most common of all types of diabetes and was the main focus of my research. To counter this disease, there is an urgent need to find alternative antidiabetic drugs to add to the current arsenal of drugs. The hypothesis of this research was that a potential source of new antidiabetic drugs could be found traditional remedies, used for many years in some societies, which are currently unknown and/or untested by modern science. To test my hypothesis, I used Hexane, Methanol + 1% Acetic Acid, 95/5 Water/Acetonitrile, and Ethyl Acetate to extract compounds from crushed Moringa oleifera seeds. I then tested these extracts for their ability to reduce glucose levels in C57BL/6J mice that had been fed a high fat diet to induce obesity. The results showed that the Methanol + 1% Acetic Acid had the greatest effect in reducing blood glucose levels in the mice. HPLC/MS analysis of the Methanol + 1% Acetic Acid extract yielded many unknown compounds but also indicated the presence of some compounds that are known to have an effect on glucose homeostasis based on current knowledge. Therefore, this research showed that Moringa oleifera, a tropical plant that has been used for its nutritional and medicinal properties, has potential as a source for novel antidiabetic drugs.
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Biology
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Rutgers University Electronic Theses and Dissertations
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ETD_7387
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electronic resource
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Note
Supplementary File: Figure 1
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1 online resource (vii, 46 p. : ill.)
Note
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M.S.
Note
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Includes bibliographical references
Subject
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Topic
Diabetes--Treatment
Subject
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Topic
Moringa oleifera
Note
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by Bryan Gachomo
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Camden Graduate School Electronic Theses and Dissertations
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rucore10005600001
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doi:10.7282/T3FF3VHT
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ETD graduate
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Rights
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The author owns the copyright to this work.
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Name
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Gachomo
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Bryan
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Permission or license
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2016-05-03 18:08:15
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Bryan Gachomo
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Rutgers University. Camden Graduate School
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Copyright protected
Availability
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Open
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Permission or license
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