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Comparison of metabolic and characteristic features of primary hyperparathyroidism patients with different intact PTH levels

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TitleInfo
Title
Comparison of metabolic and characteristic features of primary hyperparathyroidism patients with different intact PTH levels
Name (type = personal)
NamePart (type = family)
Al-Hraishawi
NamePart (type = given)
Haidar Khaioon
NamePart (type = date)
1986-
DisplayForm
Haidar Khaioon Al-Hraishawi
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Fan
NamePart (type = given)
Huizhou
DisplayForm
Huizhou Fan
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Wang
NamePart (type = given)
Xiangbing
DisplayForm
Xiangbing Wang
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Haimovich
NamePart (type = given)
Beatrice
DisplayForm
Beatrice Haimovich
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
This study is to compare primary hyperparathyroidism (PHPT) patients with different iPTH levels for serum calcium and other laboratory values. In this retrospective study, 212 patients who presented at Robert Wood Johnson Hospital were assessed for metabolic and characteristic features of PHPT. Patients were divided into two groups according to their serum intact parathyroid hormone (iPTH) levels. Student t- tests were used to compare the two groups for differences in age, body mass index (BMI), adenoma weight, and laboratory test values which included serum calcium, iPTH, 25OHD, lipid panel, serum creatinine, ALP, and 24 hr. urinary calcium. Pearson`s correlation coefficient was used to assess the relationship. Of the 212 PHPT patients, 100 (17 males and 83 females) were classified as m-iPTH group (iPTH below 140 pg/ml), whereas 112 patients (25 males and 87 females) were classified as h-iPTH group (iPTH above 140 pg/ml). Higher-iPTH patients are younger than m-iPTH patients. No statistic significant differences in BMI, T-cholesterol and TG were found between the m-iPTH and h-iPTH groups. Higher- iPTH patients compared with m- iPTH, had slightly but significantly higher calcium, lower 25OHD, lower HDL, higher ALP, and very close to have higher adenoma weight. Additionally, we found iPTH was positive correlated with serum calcium, adenoma weight, and triglyceride (TG) levels, and negatively correlated with HDL and 25OHD. Intact PTH did not correlate with BMI and T- cholesterol levels. Furthermore, 24 hr. urinary calcium and serum ALP were positively associated with iPTH levels but not significantly (P = 0.08, P = 0.09) respectively. These correlations were independent of serum calcium and 25OHD levels except TG was dependent of reduced 25OHD, while serum ALP was dependent of calcium levels. These findings from our analysis consistent with previous studies suggesting iPTH levels correlated metabolic syndrome. Additionally, our results suggest that h- iPTH patients tend to be younger ones, with lower HDL, lower 25OHD, and higher ALP. While the underline mechanisms for these changes are unclear, we speculate that the elevated iPTH levels might decrease HDL directly or indirectly through increasing insulin resistance by weight gain, and increases ALP through PTH receptors on osteoblasts. This study supported our hypothesis that iPTH levels are an important factor to contribute in the management of PHPT patients. Intact PTH levels, lipid panel, 25OHD, ALP in addition to calcium levels might also need to be considered in the therapeutic decision for PHPT patients.
Subject (authority = RUETD)
Topic
Physiology and Integrative Biology
Subject (authority = ETD-LCSH)
Topic
Hyperparathyroidism
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7271
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (ix, 50 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Haidar Khaioon Al-Hraishawi
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3W37ZF8
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Al-Hraishawi
GivenName
Haidar
MiddleName
Khaioon
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-04-15 13:40:52
AssociatedEntity
Name
Haidar Al-Hraishawi
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2016-05-24T13:45:16
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