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Characterization of IGF-1 expessing RG3.6 cells for transplantation following traumatic brain injury
Descriptive
TitleInfo
Title
Characterization of IGF-1 expessing RG3.6 cells for transplantation following traumatic brain injury
Name
(type = personal)
NamePart
(type = family)
Singh
NamePart
(type = given)
Sweta
NamePart
(type = date)
1981-
DisplayForm
Sweta Singh
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Bonder
NamePart
(type = given)
Dr. Edward
DisplayForm
Dr. Edward Bonder
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2016
DateOther
(qualifier = exact);
(type = degree)
2016-10
CopyrightDate
(encoding = w3cdtf);
(qualifier = exact)
2016
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Traumatic brain injury is one of the leading cause of neuronal damage which affects the cognitive function of the brain. Traumatic brain injury (TBI) also causes damage to the neuronal stem cells pool. IGF-1 is an important trophic factor that increases cell survival by inducing neuroprotection and anti-apoptotic activity. Therapeutic strategy to protect the neurons/neuronal stem cell pool and restoration of damage neuron and induce their ability to produce multipotent, proliferative cell that can adopt the neuronal phenotype could have beneficial effect on functional recovery of the brain after TBI. Here, we characterized and used genetically engineered rat neural stem cells, RG3.6/IGF-1+ cells, which conditionally express the insulin growth factor-1 (IGF-1). Our results demonstrate that IGF-1 induces neurogenesis in a culture system and in damaged area of the rat brain after transplantation and could have important implication in amelioration of brain damage after TBI.
Subject
(authority = RUETD)
Topic
Biology
Subject
(authority = ETD-LCSH)
Topic
Brain--Wounds and injuries
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_7454
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (v, 32 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Sweta Singh
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3319Z62
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Singh
GivenName
Sweta
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2016-07-28 02:25:56
AssociatedEntity
Name
SWETA SINGH
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
CreatingApplication
Version
1.4
ApplicationName
Mac OS X 10.11.6 Quartz PDFContext
DateCreated
(point = end);
(encoding = w3cdtf);
(qualifier = exact)
2016-09-28T16:19:54
DateCreated
(point = end);
(encoding = w3cdtf);
(qualifier = exact)
2016-09-28T16:19:54
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Statistical Profile