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Subcutaneous delivery of protein therapeutics
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Shen, Andrew Maurice. Subcutaneous delivery of protein therapeutics. Retrieved from https://doi.org/doi:10.7282/T3MS3WPG

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TitleSubcutaneous delivery of protein therapeutics
NameShen, Andrew Maurice (author); Minko, Tamara (chair); Rutgers University; Graduate School - New Brunswick
Date Created2017
Other Date2017-05 (degree)
SubjectPharmaceutical Science, Injections, Hypodermic, Drug delivery systems
Extent1 online resource (iv, 51 p. : ill.)
DescriptionSince their discovery monoclonal antibodies have been a worldwide medical phenomenon that has documented numerous novel therapeutic uses. However, delivery of such large therapeutic proteins remains a challenge in maintaining efficacious systemic concentrations as well as minimal costs. Furthermore, pharmacokinetic profiles of monoclonal antibodies begin to vary from the norm when considering obese populations and require additional analysis to avoid over-dosing. The goals of this thesis work were: 1) to develop a generic bioanalytical method for quantifying concentrations of multiple monoclonal antibodies without requiring the use of specific coating antibodies for each separate monoclonal antibody evaluated; 2) to evaluate the pharmacokinetics of rituximab in obese rats and normal-weight control animals; 3) to develop an in-vitro cell culture permeability assay for evaluating permeability properties of monoclonal antibodies.
NoteM.S.
NoteIncludes bibliographical references
Noteby Andrew Maurice Shen
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3MS3WPG
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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