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Modeling the formation of collagen-mimetic triple helices and microfibrils
Descriptive
TitleInfo
Title
Modeling the formation of collagen-mimetic triple helices and microfibrils
Name
(type = personal)
NamePart
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Karra
NamePart
(type = given)
Vyshnavi S.
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Vyshnavi S. Karra
Role
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author
Name
(type = personal)
NamePart
(type = family)
Dutt
NamePart
(type = given)
Meenakshi
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Meenakshi Dutt
Affiliation
Advisory Committee
Role
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chair
Name
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NamePart
Rutgers University
Role
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degree grantor
Name
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NamePart
School of Graduate Studies
Role
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school
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Text
Genre
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theses
OriginInfo
DateCreated
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2017
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2017-10
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2017
Place
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xx
Language
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eng
Abstract
(type = abstract)
Collagen is an abundant and integral protein within the body, due to its mechanical strength and elasticity. These properties arise from the structural hierarchy of collagen, from the peptide strands, to tropocollagen, to microfibrils, to fibers. Understanding the formation mechanisms of collagen can aid in the research of various collagen related disorders, such as heart disease, skin aging, Osteogenesis Imperfecta, etc. In this study, we simulated three short, simplified collagen peptide strands using the MARTINI coarse grained scheme. Once the tropocollagen was formed, it was replicated five more times and simulated to form a microfibril. Using mathematical equations of a helix, we characterized the tropocollagen to have a curvature (κ) of 0.9237 and a torsion (τ) of 0.6395. The maximum average interaction count occurs between two of the three strands for the tropocollagen at fifteen, suggesting in partial uncoiling of the triple helix. The average interaction counts for the microfibril are around eight, suggesting that the formation mechanism is the individual peptide strands bundling to form a microfibril-like structure, rather than forming tropocollagensand then microfibris.
Subject
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Topic
Chemical and Biochemical Engineering
Subject
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Topic
Collagen
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Rutgers University Electronic Theses and Dissertations
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ETD_8320
PhysicalDescription
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (vi, 48 p. : ill.)
Note
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M.S.
Note
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Includes bibliographical references
Note
(type = statement of responsibility)
by Vyshnavi S. Karra
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School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3959MQW
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Karra
GivenName
Vyshnavi
MiddleName
S.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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2017-08-31 10:42:09
AssociatedEntity
Name
Vyshnavi Karra
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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ETD
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windows xp
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