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A prospective study of cancer risk among the agricultural health study farm spouses associated with personal use of organochlorine insecticides
Descriptive
TitleInfo
Title
A prospective study of cancer risk among the agricultural health study farm spouses associated with personal use of organochlorine insecticides
Name
(type = personal)
NamePart
(type = family)
Louis
NamePart
(type = given)
Lydia M.
NamePart
(type = date)
1981-
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Lydia M. Louis
Role
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(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Robson
NamePart
(type = given)
Mark
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Mark Robson
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Buckley
NamePart
(type = given)
Brian
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Brian Buckley
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Gochfeld
NamePart
(type = given)
Michael
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Michael Gochfeld
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
School of Graduate Studies
Role
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school
TypeOfResource
Text
Genre
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theses
OriginInfo
DateCreated
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2017
DateOther
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2017-10
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2017
Place
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xx
Language
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(type = code)
eng
Abstract
(type = abstract)
BACKGROUND: Organochlorine insecticides (OCs) have historically been used worldwide to control insects, although most have now been banned in developed countries. Evidence for an association between OC exposures and cancer predominantly comes from occupational and population based-studies among men. We evaluated the association between the use of specific OCs and cancer among the female spouses of pesticide applicators in the Agricultural Health Study. METHODS: At enrollment (1993–1997), spouses of private applicators in the cohort provided information about their own personal use of pesticides, including seven OCs (aldrin, chlordane, dieldrin, DDT, heptachlor, lindane, and toxaphene), and information on potential confounders. We used Poisson regression to estimate relative risks (RRs) and 95% confidence intervals (CIs) for cancers (n≥3 exposed cancer cases) reported to state cancer registries from enrollment through 2012 (North Carolina) and 2013 (Iowa), and the self-reported personal use OCs. RESULTS: Among 28,909 female spouses, 2,191 (7.58%) reported ever use of at least one OC, of whom 287 were diagnosed with cancer. Most cancers were not associated with OC use. Risk of glioma was increased among users of at least one OC (Nexposed=11, RR=3.52, 95%CI 1.72-7.21) and specifically among lindane users (Nexposed=3, RR=4.45, 95%CI 1.36-14.55). Multiple myeloma was associated with chlordane (Nexposed=6, RR=2.71, 95%CI 1.12-6.55). Based on 3 exposed cases each, there were also positive associations between pancreatic cancer and lindane, and ER-PR- breast cancer and dieldrin. No other associations with breast cancer were found. CONCLUSIONS: Overall, there were some associations with OC use and cancer incidence, however we were limited by the small number of exposed cancer cases. Future research should attempt to expand on these findings by assessing environmental sources of OC exposures, to fully evaluate the role of OC exposures on cancer risk in women.
Subject
(authority = RUETD)
Topic
Toxicology
Subject
(authority = ETD-LCSH)
Topic
Organochlorine compounds
Subject
(authority = ETD-LCSH)
Topic
Pesticides
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_8427
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (ix, 52 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Lydia M. Louis
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier
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rucore10001600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T39W0JK3
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Louis
GivenName
Lydia
MiddleName
M.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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0000-00-00 00:00:00
AssociatedEntity
Name
Lydia Louis
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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windows xp
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2017-10-10T14:39:17
DateCreated
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2017-10-10T14:39:17
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