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Non-destructive biomechanical testing of tissues using a vibrational optical coherence tomography setup

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Title
Non-destructive biomechanical testing of tissues using a vibrational optical coherence tomography setup
Name (type = personal)
NamePart (type = family)
Shah
NamePart (type = given)
Ruchit
NamePart (type = date)
1987-
DisplayForm
Ruchit Shah
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Silver
NamePart (type = given)
Frederick H
DisplayForm
Frederick H Silver
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
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NamePart (type = family)
Pierce
NamePart (type = given)
Mark C
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Mark C Pierce
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Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Boustany
NamePart (type = given)
Nada
DisplayForm
Nada Boustany
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Salafia
NamePart (type = given)
Carolyn M
DisplayForm
Carolyn M Salafia
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (qualifier = exact); (type = degree)
2018-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The mechanical properties of tissues and implants contribute to their physiological functionality, and have been vast areas of research in fields such as Dermatology, Cardiology, Neurology, Ophthalmology, Orthopedics and Urology. Several tests and modalities have been used to measure the mechanical properties of tissues and implants including tensile, compressive, shear, and bending in one or more axial directions. However, majority of these tests are destructive, rendering the material unusable post-testing; whereas most of the non-destructive imaging modalities such as magnetic resonance imaging (MRI), nuclear magnetic resonance (NMR) and ultrasound are costly and have lower spatial resolution. Optical coherence tomography (OCT) is an optical imaging modality that provides high-resolution images and has been extended to optical coherence elastography (OCE) in various embodiments to compute the mechanical properties of biological tissues. The application of elastography in computing biomechanical properties of tissues such as elastic moduli generally excludes the viscosity component of the tissues. The computation of viscoelastic properties using OCE is still in a nascent stage but has a promising future. The primary goal of this dissertation was to develop and engineer a vibrational OCT system that performs nondestructive computation of viscoelastic properties of monophasic and composite biological tissues and implants. The underlying hypotheses of this dissertation are: i) the modulus of a tissue computed by using its resonant frequency will be comparable to its elastic modulus obtained from the uniaxial tensile testing method; ii) the resonant frequency and thereby the computed modulus will vary with strain; iii) tissues will demonstrate elastic and viscoelastic properties when pulse-vibrated at resonant and non-resonant frequencies, respectively; and iv) the moduli obtained from the vibrational OCT setup will differ between healthy and diseased tissues. To validate the efficacy of vibrational OCT system to measure elastic modulus of mono- and multi-phasic biological tissues, a benchtop OCT system with an external speaker was set up to vibrate clamped samples with a continuous sinusoidal force at different strains. The resonant frequency of the samples was identified by observing the speaker-induced tissue displacements over a frequency range of 50 to 1000Hz, and their physical dimensions were used to determine their elastic moduli using the vibrational setup. These moduli were almost identical to those obtained using the gold standard method of uniaxial tensile testing. Multiphasic samples (bovine cartilage and pigskin) exhibited multiple resonant peaks. In order to compute viscoelastic properties of tissues, the calibrated vibrational OCT setup was modified to generate a burst of 3 cycles of sinusoidal input waves. The samples demonstrated response similar to that of an underdamped system. The half-power bandwidth method was utilized to determine the loss modulus percent of the samples at different strains. The results showed that the viscous component of the dermis is strongest under 100Hz and that the materials exhibit almost purely elastic response at resonant frequencies. The vibrational OCT setup was also used to characterize/ differentiate chorionic plate tissues from human placentas belonging to early term, normal and abnormal pregnancies. Each group showed distinct biomechanical properties reflecting altered tissue compositions across time and disease state.
Subject (authority = RUETD)
Topic
Biomedical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8656
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xv, 90 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Biomechanics
Note (type = statement of responsibility)
by Ruchit Shah
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T31V5J5S
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Shah
GivenName
Ruchit
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-01-11 09:58:22
AssociatedEntity
Name
Ruchit Shah
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-01-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2019-01-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 31st, 2019.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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