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Comparative analysis of clinical and behavioral factors in diabetic and non-diabetic inflammatory disease population

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TitleInfo
Title
Comparative analysis of clinical and behavioral factors in diabetic and non-diabetic inflammatory disease population
Name (type = personal)
NamePart (type = family)
Gadhia
NamePart (type = given)
Hetu
NamePart (type = date)
1989-
DisplayForm
Hetu Gadhia
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Srinivasan
NamePart (type = given)
Shankar
DisplayForm
Shankar Srinivasan
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Coffman
NamePart (type = given)
Frederick
DisplayForm
Frederick Coffman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Joshi
NamePart (type = given)
Hetal
DisplayForm
Hetal Joshi
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Health Professions
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (qualifier = exact); (type = degree)
2018-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Inflammation is characterized as the response of vascularized tissues to injury or infection. Inflammation usually occurs as a protective response to an injury or destruction of tissue, which intends to destroy the injured tissue. Arthritis and ulcerative colitis are two of the highly prevalent inflammatory diseases amongst US population. In addition, type-2 diabetes is one of the highly prevalent comorbidities in current US population, however very few studies have investigated the relationship between the highly prevalent inflammatory disease and the type-2 diabetes. In the current study, we aim to identify the factors that influence the prevalence of these inflammatory diseases in type-2 diabetic population. These factors that affect the prevalence of inflammatory disease patients with diabetes are characterized in two categories, clinical factors and behavioral factors. Clinical factors are defined as biological factors that cannot be easily modified and can be quantified clinically or for which a clinical diagnosis exist. Clinical factors that are analyzed in this study are BMI and the effects of sleep on the prevalence of the inflammatory diseases amongst diabetic patients. On the other hand, behavioral factors are characterized by factors that are controlled externally and can be modified and rectified very quickly. Behavioral factors investigated in this study are smoking status, alcohol consumption status and presence of physical activity. The goal of this study is to assess the risk associated with the prevalence of these behavioral and clinical factors in association with prevalence of the two inflammatory diseases in diabetic populations. The odds ratio between the prevalence of these factors and the prevalence of arthritis, ulcerative colitis or both combined amongst diabetic patients are analyzed using logistic regression. Significant observations indicated that clinical factors play a more effective role amongst patients with arthritis who have diabetes compared to arthritis patients without diabetes. The odds of arthritis in diabetic patients increases by 2.39 folds amongst patients who are obese compared to the arthritis patients who are obese but do not have diabetes. In addition, arthritis patients with diabetes show significantly higher mean BMI of 31.04 kg/m2 compared to arthritis patient without diabetes with a mean BMI of 27.68 kg/m2. On the contrary, exercise decreases odds of arthritis by 1.587 folds in non-diabetic population compared to diabetic population. Amongst patients with ulcerative colitis and diabetes, increased BMI results in higher odds of prevalence of ulcerative colitis by 2.697 folds compared to patients without diabetes. Additionally, ulcerative colitis patients with diabetes have significantly higher BMI compared to patients without diabetes. We also investigated the effects and prevalence of these inflammatory diseases on healthcare cost and treatment cost. The study indicated diabetes as one of the major risk factors for arthritis and/or ulcerative colitis. We also identified significantly increased prevalence of negative factors such as obesity, smoking and alcohol consumption in the inflammatory disease group compared to the healthy group. On the contrary, positive factors such as regular exercise was more prevalent in patient group without diabetes compared to patient group with diabetes. Additionally, research with a much-balanced sample is needed to further understand the factors that may influence the prevalence of the two diseases.
Subject (authority = RUETD)
Topic
Biomedical Informatics
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8566
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xv, 148 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Inflammation
Subject (authority = ETD-LCSH)
Topic
Diabetes
Note (type = statement of responsibility)
by Hetu Gadhia
RelatedItem (type = host)
TitleInfo
Title
School of Health Professions ETD Collection
Identifier (type = local)
rucore10007400001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3V12825
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Gadhia
GivenName
Hetu
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2017-12-15 17:11:47
AssociatedEntity
Name
Hetu Gadhia
Role
Copyright holder
Affiliation
Rutgers University. School of Health Professions
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2017-12-15T21:58:24
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