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Scientific maps and innovation

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TitleInfo
Title
Scientific maps and innovation
SubTitle
impact of the human genome map on drug discovery
Name (type = personal)
NamePart (type = family)
Jayaraj
NamePart (type = given)
Sebastian
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Sebastian Jayaraj
Role
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author
Name (type = personal)
NamePart (type = family)
Gittelman
NamePart (type = given)
Michelle
DisplayForm
Michelle Gittelman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
Role
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school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (qualifier = exact); (type = degree)
2018-05
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2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Scientific mapping projects like the ongoing US BRAIN initiative and Human Cell Atlas are data and resource intensive endeavors that curate immense amounts of information. While both public and private funds support such mapping of the scientific knowledge landscape, the impact of such projects on innovation is not well understood. Innovation can be conceptualized as a spatial process, where firms and inventors search either locally or in distant, lesser explored, territories. In my dissertation, I asked whether scientific maps influence technological search, and if so how. To address this empirically, I chose the Human Genome Project (HGP) as my context and asked how it affected drug discovery. HGP, the largest publicly-funded biology project, released the complete human genome map in 2000, enabling scientists to identify and focus on disease-causing genes as targets for drug discovery. Using a novel dataset of chemistry drug patents, I tracked firm search processes pre- and post-HGP. To measure how the HGP map impacts firm exploration, I also developed a novel method based on chemical similarities to capture search trajectories over time. My conclusions on how the HGP map influenced inventive activity, innovation strategy and outcomes are detailed in three essays and build on existing theories in the innovation literature. Briefly, I found that the HGP map increased the rate of novel compound production, exploration and impacted firm innovation strategies. This was influenced by prior firm knowledge, market competition and product market specialization. This study informs on mechanisms by which basic science driven scientific maps influence industry innovation. My findings bear implications on public policy, R&D management and firm strategy.
Subject (authority = RUETD)
Topic
Management
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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ETD_8932
PhysicalDescription
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electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xii, 186 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Gene mapping
Note (type = statement of responsibility)
by Sebastian Jayaraj
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3NK3JFF
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

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The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Jayaraj
GivenName
Sebastian
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-04-19 17:13:35
AssociatedEntity
Name
Sebastian Jayaraj
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2018-04-23T12:51:12
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