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Practical application of simulation and campaign scheduling of the manufacturing process based on monoclonal antibody
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Prabhu, Siddharth. Practical application of simulation and campaign scheduling of the manufacturing process based on monoclonal antibody. Retrieved from https://doi.org/doi:10.7282/t3-wx8z-kg72

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TitlePractical application of simulation and campaign scheduling of the manufacturing process based on monoclonal antibody
NamePrabhu, Siddharth (author); Ramachandran, Rohit (chair); Ierapetritou, Marianthi (internal member); Singh, Ravendra (internal member); Rutgers University; School of Graduate Studies
Date Created2018
Other Date2018-10 (degree)
SubjectChemical and Biochemical Engineering, Monoclonal antibodies
Extent1 online resource (71 pages : illustrations)
DescriptionMonoclonal antibodies are the fastest growing segment of pharmaceutical molecules. Currently, they are used as diagnostics, therapeutics for various medical uses as well as in protein purification. They are among the costliest drugs available in the market. In recent years, due to the competitive pharmaceutical market and incentives for antibody development, biotech industries are investing in novel and advanced technologies to increase the productivity as well as the efficiency of the process.
This project discusses the use of commercially available simulation and scheduling tools to increase the efficiency of the manufacturing process based on monoclonal antibody (mAb). SuperPro Designer and SchedulePro (Intelligen, Inc) is used as a recipe based scheduling tool while VirtECS Scheduler (APC, Inc) is used as a mathematical optimization tool. The manufacturing facility of Eli Lilly and Company located in Kinsale, Ireland is modeled for this thesis. A comparison of these two tools to determine an optimal schedule is obtained. The results show detailed equipment tracking, increased scheduling flexibility, faster facility fit, real-time scheduling and automatic conflict resolution. Increasing the efficiency of the process as well as playing a significant role in day-to-day activities and therefore saving valuable employee time.
NoteM.S.
NoteIncludes bibliographical references
Noteby Siddharth Prabhu
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/t3-wx8z-kg72
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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