RUcore: Rutgers University Community Repository
An evaluation and feasibility study for the need of new dosimetric tools and metrics for lung cancer patients receiving radiotherapy
Descriptive
TitleInfo
Title
An evaluation and feasibility study for the need of new dosimetric tools and metrics for lung cancer patients receiving radiotherapy
Name
(type = personal)
NamePart
(type = family)
Nawaz
NamePart
(type = given)
Ahmed Omer
NamePart
(type = date)
1977-
DisplayForm
Ahmed Omer Nawaz
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Gohel
NamePart
(type = given)
Suril
DisplayForm
Suril Gohel
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Srinivasan
NamePart
(type = given)
Shankar
DisplayForm
Shankar Srinivasan
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Coffman
NamePart
(type = given)
Frederick
DisplayForm
Frederick Coffman
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
School of Health Professions
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2019
DateOther
(qualifier = exact);
(type = degree)
2019-01
CopyrightDate
(encoding = w3cdtf)
2019
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Radiation oncology has made great strides forward specifically in the treatment of lung cancer. However, these advances have themselves delivered new questions that clinicians face when attempting to treat tumors in the lungs. The first of which is how to best deliver an increasing radiation dose to a small moving target. The second is how best to estimate and predict the damage to healthy lung tissue as a consequence of these higher doses.
Clinicians and academics from around the country have tabulated data, the purpose of which is to assess the risk of radiation damage to their patients during and after treatment. The consensus among these various groups is that the risk is best assessed by two or three volumetric data points. These dose indices are believed to allow clinicians to better assess toxicity endpoints in the lungs. The literature is rich with this guidance. However, that same literature search will also reveal that there is little to no data that focuses on the changes that occur in the previously mentioned evaluation metrics during respiration. The “V’s” in the V5 and the V20 are incorrectly assumed constant and unchanging.
This retrospective analysis of 10 lung cancer patients shows that those clinically used metrics of evaluation that are treated as static numbers are in fact dynamic. It shows the degree to which these volumetric numbers vary from what is currently accepted. And it presents a more stable, mass-based alternative to volumetric metrics that may be more suited to assessing dose to healthy lung tissue during radiation therapy due to its stability throughout the patient’s breathing cycle.
These mass-based alternative metrics are derived from each patient’s own lung volume using novel techniques involving the CT Hounsfield units. Yet, through ANOVA and two sample t-tests they show statistical significance in their difference from the volume in a rate of change analysis. The mass metrics also present more stability in their rate of change via one sample t-test and also exhibit lower standard deviations in all 10 patient’s breathing cycle and therefore has the potential to replace the current metrics for assessing radiation toxicity.
Clinicians and academics from around the country have tabulated data, the purpose of which is to assess the risk of radiation damage to their patients during and after treatment. The consensus among these various groups is that the risk is best assessed by two or three volumetric data points. These dose indices are believed to allow clinicians to better assess toxicity endpoints in the lungs. The literature is rich with this guidance. However, that same literature search will also reveal that there is little to no data that focuses on the changes that occur in the previously mentioned evaluation metrics during respiration. The “V’s” in the V5 and the V20 are incorrectly assumed constant and unchanging.
This retrospective analysis of 10 lung cancer patients shows that those clinically used metrics of evaluation that are treated as static numbers are in fact dynamic. It shows the degree to which these volumetric numbers vary from what is currently accepted. And it presents a more stable, mass-based alternative to volumetric metrics that may be more suited to assessing dose to healthy lung tissue during radiation therapy due to its stability throughout the patient’s breathing cycle.
These mass-based alternative metrics are derived from each patient’s own lung volume using novel techniques involving the CT Hounsfield units. Yet, through ANOVA and two sample t-tests they show statistical significance in their difference from the volume in a rate of change analysis. The mass metrics also present more stability in their rate of change via one sample t-test and also exhibit lower standard deviations in all 10 patient’s breathing cycle and therefore has the potential to replace the current metrics for assessing radiation toxicity.
Subject
(authority = RUETD)
Topic
Biomedical Informatics
Subject
(authority = ETD-LCSH)
Topic
Lung -- Cancer
Subject
(authority = ETD-LCSH)
Topic
Radiation -- Toxicology
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_9397
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (89 pages : illustrations)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Ahmed Omer Nawaz
Subject
(authority = ETD-LCSH)
Topic
Radiation dosimetry
RelatedItem
(type = host)
TitleInfo
Title
School of Health Professions ETD Collection
Identifier
(type = local)
rucore10007400001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/t3-fpa1-bq15
Genre
(authority = ExL-Esploro)
ETD doctoral
Back to the top
Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Nawaz
GivenName
Ahmed
MiddleName
Omer
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2018-12-05 16:18:51
AssociatedEntity
Name
Ahmed Nawaz
Role
Copyright holder
Affiliation
Rutgers University. School of Health Professions
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top
Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
CreatingApplication
Version
1.4
ApplicationName
GPL Ghostscript 9.06
DateCreated
(point = start);
(encoding = w3cdtf);
(qualifier = exact)
2018-12-07T00:04:31
DateCreated
(point = start);
(encoding = w3cdtf);
(qualifier = exact)
2018-12-07T00:04:31
Back to the top
Statistical Profile