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Multidimensional hybrid nanomaterial approaches for therapeutic and diagnostic applications

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TitleInfo
Title
Multidimensional hybrid nanomaterial approaches for therapeutic and diagnostic applications
Name (type = personal)
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Chueng
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Sy-Tsong Dean
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1988-
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Sy-Tsong Dean Chueng
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author
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Lee
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Ki-Bum
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Ki-Bum Lee
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Advisory Committee
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chair
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Brennan
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John
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John Brennan
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Advisory Committee
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internal member
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Garfunkel
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Eric
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Eric Garfunkel
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Advisory Committee
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internal member
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Young
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Wise
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Wise Young
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Advisory Committee
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outside member
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Rutgers University
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degree grantor
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School of Graduate Studies
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theses
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2019
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2019-01
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2019
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xx
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eng
Abstract (type = abstract)
Nanomaterials are highly versatile and allow us to effectively and dynamically control a myriad of biomedical application from stem cell differentiation to diagnostics and translational therapeutics. While the scientific community has made tremendous strides in understanding disease and treatments, the complexities of disease and injuries still undermine the full realization of therapies. To this end, this dissertation will focus on the approaches within the novel nanotechnology toolbox for addressing multiple challenges in the field of regenerative medicine with the ultimate goal to regrow and reform damaged tissues and organs. Specifically, this dissertation addresses the regeneration of neural tissues within the central nervous system as the regeneration of such tissue is extremely challenging in the first two decades of the 21$^{st}$ century.
The first part of the dissertation will focus on the innovative insoluble extracellular approaches for controlling the differentiation of neural stem cells (NSCs) into neurons and supporting cells such as oligodendrocytes. Traditionally, biologists have focused on introducing exogenous materials such as proteins and chemical factors to induce specific stem cell differentiation. The goal of our novel insoluble nanomaterial approaches is to uncover the interaction between cells and their surrounding environments for differentiation. The second part of the thesis will focus on the clinical translational approaches of nanomaterials. Through a novel, non-viral transient gene manipulation method developed by Prof. Lee research laboratory, NanoScript, a nanoparticle-based synthetic transcription factor was tasked to regenerate axon in spinal cord injury. This demonstration is tremendous progress in regenerative medicine as it holds a promise for the regulation of every gene expression in a living biological system. Finally, this dissertation will focus on the development of highly sensitive, selective, real-time, and non-invasive characterizations of stem cell differentiation. The development of such an approach will have a significant impact on cell-based therapy. By overcoming the destructive nature of traditional cellular characterization methods, the clinicians can confirm the mature differentiation of stem cells before transplantation to completely avoid potential tumor formation. As such, more cell-based therapies will find their ways into clinical applications.
Altogether, this dissertation covers the widely collaborative nanomaterial-based approaches from guiding the differentiation of stem cell, biosensing, and non-viral nanoparticle for gene expression regulation, to the transplantable nanofiber-nanomaterial hybrid scaffold with the foundation of nanochemistry with well-defined biochemical, chemical, and physical compositions, shapes, and properties.
Subject (authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject (authority = ETD-LCSH)
Topic
Nanostructured materials
Subject (authority = ETD-LCSH)
Topic
Central nervous system -- Regeneration
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Rutgers University Electronic Theses and Dissertations
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ETD_9473
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electronic resource
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Extent
1 online resource (218 pages : illustrations)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Sy-Tsong Dean Chueng
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School of Graduate Studies Electronic Theses and Dissertations
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Identifier (type = doi)
doi:10.7282/t3-hd9x-rs68
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
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Name
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Chueng
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Sy-Tsong
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Dean
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Permission or license
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2019-01-02 17:16:15
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Sy-Tsong Chueng
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Rutgers University. School of Graduate Studies
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2019-01-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2021-01-30
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 30th, 2021.
Copyright
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Copyright protected
Availability
Status
Open
Reason
Permission or license
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