Design, fabrication, and manipulation of a multi-degree of freedom micro-manipulator for large-range, three-dimensional operation on atomic force microscope
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Patel, Parth. Design, fabrication, and manipulation of a multi-degree of freedom micro-manipulator for large-range, three-dimensional operation on atomic force microscope. Retrieved from https://doi.org/doi:10.7282/t3-a7fj-wx98
TitleDesign, fabrication, and manipulation of a multi-degree of freedom micro-manipulator for large-range, three-dimensional operation on atomic force microscope
DescriptionAFM (Atomic Force Microscope) has become an enabling tool in a wide range of areas ranging from biology, material sciences to other nanosciences and nanoengineering areas. However, currently AFM operation has been limited to a relatively small sample area (below around 0.1~mm by 0.1~mm) and 2-D samples only. On the contrary, froniter and emerging applications in areas such as biology demands and require an AFM capable of imaging and/or measuring properties of samples over a much larger range (in mm size or even larger), and on 3-dimensional samples such as 3-D organoid cell culture.
This M.S. research work is focused on the creation of a multi-degree of freedom micro-manipulator for large-range, 3-dimensional operation of a sample on AFM. Particularly, the needs and constraints arising from integrating the AFM system to an inverted optical microscope for (optical-AFM) coordinated operation are accounted for and addressed in the design and fabrication of the manipulator. A robust stage with minimal noise and vibration needs to be designed to fulfill the goal of micro-manipulation with maximum possible accuracy. During this a '3-DOF RSR (Revolute-Spherical-Revolute) Parallel Delta manipulator' combined with '2-DOF RR (Revolute) Serial perpendicular axis manipulator', kinematic mechanisms are coupled together to achieve micro-manipulation. High accuracy with high dynamic characteristics of parallel manipulator provides precise positioning by translation motion and two revolute joints facilitates precise orientation by rotational motion. The decoupling of the translation motion from the rotational motion of the sample helps in making a system independent to other while allowing simultaneous operation. The use of small disk design for sample holder to rotate sample, minimizes the disturbances to the solution. Design, kinematic analysis, fabrication, motion simulation, and preliminary motion control in experiments for the independent and combined configuration are covered in this research work.