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Extrastriatal GABAA receptors as a nondopaminergic target in the treatment of motor symptoms of Parkinson's disease and levodopa-induced dyskinesia
Descriptive
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Title
Extrastriatal GABA<sub>A</sub> receptors as a nondopaminergic target in the treatment of motor symptoms of Parkinson's disease and levodopa-induced dyskinesia
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Title
Extrastriatal GABAA receptors as a nondopaminergic target in the treatment of motor symptoms of Parkinson's disease and levodopa-induced dyskinesia
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Assini
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Robert
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1986-
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Robert Assini
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author
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Abercrombie
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Elizabeth D
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Elizabeth D Abercrombie
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Advisory Committee
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chair
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Mena-Segovia
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Juan
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Juan Mena-Segovia
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James M
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James M Tepper
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Advisory Committee
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Polack
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Pierre-Olivier
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Pierre-Olivier Polack
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Koos
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Tibor Koos
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internal member
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Lobb
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Collin J
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Collin J Lobb
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Rutgers University
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Graduate School - Newark
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theses
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ETD doctoral
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2019
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2019-10
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2019
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English
Abstract
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Parkinson’s disease is a progressive neurodegenerative disorder resulting from the death of the dopaminergic nigrostriatal projection to the basal ganglia. Extrastriatal nuclei within this circuit have been shown to exhibit synchronous oscillatory activity entrained to excessive cortical beta oscillations following dopamine depletion. Zolpidem binds to GABAA receptors at the benzodiazepine site, potentiating inhibitory postsynaptic currents with selectivity for receptors expressing the α1 subunit. Coincidentally, the nuclei expressing the α1 subunit within the BG are also those that have been shown to have increased synchronous bursting activity in a dopamine-depleted state. We hypothesize that this differential expression of the α1 subunit indicates zolpidem-sensitive GABAA receptors may constitute a potential non-dopaminergic therapeutic intervention in the treatment of PD motor symptoms. The work described in this dissertation explores this possibility using behavioral neuropharmacology and analytical chemistry.
Subject
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Topic
Neuroscience
Subject
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Topic
Parkinson's disease -- Treatment
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Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - Newark Electronic Theses and Dissertations
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rucore10002600001
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ETD_10334
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doi:10.7282/t3-q4gd-vx26
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1 onlin resource (xv, 173 pages) : illustrations
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Ph.D.
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Includes bibliographical references
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Rights
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The author owns the copyright to this work.
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Assini
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Robert
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2019-09-25 20:33:05
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Robert Assini
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Rutgers University. Graduate School - Newark
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2019-10-31
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2020-10-30
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2020.
Copyright
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Copyright protected
Availability
Status
Open
Reason
Permission or license
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