Staff View
Investigation of a novel decision support metric for head and neck adaptive radiation therapy (ART) using a real-time in-vivo portal dosimetry system

Descriptive

TitleInfo
Title
Investigation of a novel decision support metric for head and neck adaptive radiation therapy (ART) using a real-time in-vivo portal dosimetry system
Name (type = personal)
NamePart (type = family)
Lim
NamePart (type = given)
Seng Boh
NamePart (type = date)
1971-
DisplayForm
Seng Boh Lim
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Coffman
NamePart (type = given)
Frederick
DisplayForm
Frederick Coffman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Health Professions
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2020
DateOther (encoding = w3cdtf); (qualifier = exact); (type = degree)
2020-01
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
In adaptive radiation therapy (ART) of head and neck cancer, any significant anatomical changes observed are used to adapt the treatment plan to maintain target coverage without elevating the xerostomia risk. However, the additional resources required for ART pose a challenge for broad-based implementation. It is hypothesized that the transit fluence change is associated with volumetric change in the vicinity of the target and therefore can be used as a decision support metric (DMS) for ART. This was evaluated by comparing the fluence with volumetric changes in twenty-four patients. Transit fluence was measured by an in-vivo portal dosimetry system (RTPD). Weekly cone beam computed-tomography (CBCT) was used to determine volume change in the rectangular region of interest (ROI) from condyloid process to C6. The integrated fluence through the ROI and the salivary glands (SG) on the day of the CBCT scan was calculated with the first treatment as the baseline. The correlation between fluence and volume changes was determined. Logistic regression was also used to associate the 5% ROI volume reduction replanning trigger-point and the fluence change. The model was assessed by a chi-squared test. The area (AUC) under the receiver operating characteristic curve (ROC) was also determined. The xerostomia risk was assessed by the scores change of the patients’ MD Anderson Dysphagia Inventory (MDADI). The association of the MDADI with age, gender, mean dose to SG, weight, volumetric and fluence changes were assessed using Spearman rank-correlation. A total of 108 pairs of CBCT and RTPD measurements were obtained. The correlation between fluence and volumetric changes were found to be -0.837 (p-value<0.001). The AUC of the ROC was found to be 0.91. The correlation between SG-specific fluence and volumetric changes was found to be -0.62 (p-value<0.001). Twenty-one patients responded to the MDADI. Fluence and volumetric changes were found to have association with the physical, functional and total MDADI changes. No significant association with age, gender, and weight change were found. A transit fluence based DSM is not only a viable alternative to serial CBCT in assisting clinicians in the patient selection, but also lowers the resource barrier of ART implementation.
Subject (authority = RUETD)
Topic
Biomedical Informatics
Subject (authority = local)
Topic
Transit dosimetry
Subject (authority = LCSH)
Topic
Radiation dosimetry
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_10278
PhysicalDescription
Form (authority = gmd)
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xiii, 104 pages) : illustrations
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
RelatedItem (type = host)
TitleInfo
Title
School of Health Professions ETD Collection
Identifier (type = local)
rucore10007400001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/t3-ntgk-gf35
Genre (authority = ExL-Esploro)
ETD doctoral
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Lim
GivenName
Seng
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-09-20 10:15:51
AssociatedEntity
Name
Seng Lim
Role
Copyright holder
Affiliation
Rutgers University. School of Health Professions
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
CreatingApplication
Version
1.5
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-09-20T10:13:57
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-09-20T10:13:57
ApplicationName
Acrobat Distiller 10.1.4 (Windows)
Back to the top
Version 8.5.3
Rutgers University Libraries - Copyright ©2024